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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4loqSB4Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4loqSB4Mitogen-activated protein kinase 14/1.000
4lopSB4Mitogen-activated protein kinase 14/0.763
3hl7I47Mitogen-activated protein kinase 14/0.524
3gubGUBDeath-associated protein kinase 12.7.11.10.465
4looSB4Mitogen-activated protein kinase 14/0.464
3nww3NWMitogen-activated protein kinase 14/0.454
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3kf7L9GMitogen-activated protein kinase 14/0.447
3bgbLJGGag-Pol polyprotein3.4.23.160.446
3ttp017Gag-Pol polyprotein3.4.23.160.446
1k6cMK1Gag-Pol polyprotein3.4.23.160.445
3sm2478Putative gag-pro-pol polyprotein/0.445
4zseANPEpidermal growth factor receptor2.7.10.10.445
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.445
1c6yMK1Protease/0.444
3nu4478Gag-Pol polyprotein3.4.23.160.444
1xl5190Gag-Pol polyprotein3.4.23.160.443
1jld0PPGag-Pol polyprotein/0.442
2he5NDPAldo-keto reductase family 1 member C211.1.10.442
3livE16Protease/0.442
2g263LGRenin3.4.23.150.441
2gjlFMNNitronate monooxygenase1.13.12.160.440
3nwxKVSGag-Pol polyprotein3.4.23.160.440
3t113T1Gag-Pol polyprotein3.4.23.160.440