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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lfgIPEPutative geranyltranstransferase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4lfgIPEPutative geranyltranstransferase/1.000
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.555
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.554
3krfIPEGeranyl diphosphate synthase large subunit/0.545
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.545
3rywK9HFarnesyl pyrophosphate synthase, putative/0.537
3krfDSTGeranyl diphosphate synthase large subunit/0.535
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.524
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.523
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.522
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.515
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.513
1rqjRISFarnesyl diphosphate synthase2.5.1.100.511
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.498
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.495
3rbmB73Farnesyl pyrophosphate synthase, putative/0.491
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.481
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.478
1yv5RISFarnesyl pyrophosphate synthase2.5.1.100.472
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.100.472
3oabDSTGeranyl diphosphate synthase large subunit/0.461
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.458
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.451
4dwb0M7Farnesyl pyrophosphate synthase/0.443