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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ldjGDPGTPase KRas

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4ldjGDPGTPase KRas/1.000
4ql3GDPGTPase KRas/0.809
4epxGDPGTPase KRas/0.782
4q03GDPGTPase KRas/0.759
4q02GDPGTPase KRas/0.643
4tq9GDPGTPase KRas/0.613
4lpkGDPGTPase KRas/0.612
4l8gGDPGTPase KRas/0.607
3kkqGDPRas-related protein M-Ras/0.600
4obeGDPGTPase KRas/0.591
4epwGDPGTPase KRas/0.582
4o2rGDPGTP-binding protein Rheb/0.582
2fe4GDPRas-related protein Rab-6B/0.580
4lv6GDPGTPase KRas/0.578
2rggGNPGTPase HRas/0.576
3kkoGNPRas-related protein M-Ras/0.575
1x1rGDPRas-related protein M-Ras/0.574
4l9sGDPGTPase HRas/0.574
4wa7GDPGTPase KRas/0.572
4dsuGDPGTPase KRas/0.560
3k9lGNPGTPase HRas/0.556
4lrwGDPGTPase KRas/0.552
3ddcGNPGTPase HRas/0.550
3rs5GNPGTPase HRas/0.549
2rgbGNPGTPase HRas/0.548
4hdqGNPRas-related protein Rap-1b/0.548
4xvqGNPGTPase HRas/0.548
3i3sGNPGTPase HRas/0.547
2ce2GDPGTPase HRas/0.541
4dltGNPGTPase HRas/0.541
3lbhGNPGTPase HRas/0.540
3oivGNPGTPase HRas/0.538
3rslGNPGTPase HRas/0.538
3x1zGNPRas-related protein Rap-1b/0.538
2c5lGTPGTPase HRas/0.537
3tgpGNPGTPase HRas/0.537
3rs4GNPGTPase HRas/0.532
3tsoGNPRas-related protein Rab-25/0.532
4dsnGCPGTPase KRas/0.532
4g0nGNPGTPase HRas/0.532
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.531
4dlxGNPGTPase HRas/0.531
4xvrGNPGTPase HRas/0.531
2bmeGNPRas-related protein Rab-4A/0.529
1zbdGTPRas-related protein Rab-3A/0.528
2fg5GNPRas-related protein Rab-31/0.528
3cphGDPRas-related protein SEC4/0.528
3l8yGNPGTPase HRas/0.526
4dlvGNPGTPase HRas/0.526
5difGNPGTP-binding nuclear protein Ran/0.525
3v4fGNPGTPase HRas/0.524
3rs0GNPGTPase HRas/0.523
2rgcGNPGTPase HRas/0.522
1d5cGDPGTPase (Rab6)/0.520
1e96GTPRas-related C3 botulinum toxin substrate 1/0.520
2mscGDPMHC class I alpha chain/0.519
3pitGNPRas-related protein M-Ras/0.519
5dhaGNPGTP-binding nuclear protein Ran/0.518
4dlzGNPGTPase HRas/0.517
4dlwGNPGTPase HRas/0.516
3oiuGNPGTPase HRas/0.515
3lbiGNPGTPase HRas/0.513
5b2zGNPGTPase HRas/0.513
1npdNADQuinate/shikimate dehydrogenase/0.512
3kudGDPGTPase HRas/0.512
2oo7AP5Adenylate kinase/0.510
4nyjGNPGTPase HRas/0.510
1zd9GDPADP-ribosylation factor-like protein 8A/0.509
1z2aGDPRas-related protein Rab-23/0.508
2rgeGNPGTPase HRas/0.507
3lbnGNPGTPase HRas/0.507
1zc4GNPRas-related protein Ral-A/0.506
3oiwGNPGTPase HRas/0.506
1rd4L08Integrin alpha-L/0.505
3qbtGNPRas-related protein Rab-8A/0.504
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.503
3bbpGTPRas-related protein Rab-6A/0.501
3rs7GNPGTPase HRas/0.501
4hdoGNPRas-related protein Rap-1b/0.501
1lfdGNPGTPase HRas/0.499
4uj3GNPRas-related protein Rab-11A/0.499
1kmqGNPTransforming protein RhoA/0.498
1yu9GNPRas-related protein Rab-4A/0.498
3x1wGDPRas-related protein Rap-1b/0.498
4dlsGNPGTPase HRas/0.498
3kucGDPRas-related protein Rap-1A/0.495
1n6lGTPRas-related protein Rab-5A/0.494
1xtsGTPGTP-binding protein Rheb/0.494
3k8yGNPGTPase HRas/0.494
4kgkGTPUncharacterized protein/0.494
4p9dTMPDeoxycytidylate deaminase/0.494
5jljGNPGTP-binding nuclear protein Ran/0.493
1qrsATPGlutamine--tRNA ligase6.1.1.180.492
3p67FMNPentaerythritol tetranitrate reductase/0.491
1e0jANPDNA primase/helicase2.7.70.490
1oixGDPRas-related protein Rab-11A/0.489
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.489
3cobADPKinesin heavy chain-like protein/0.489
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.489
4dsoGSPGTPase KRas/0.488
4rkfGNPRas-related protein Rab-3/0.488
1zc3GNPRas-related protein Ral-A/0.486
1g16GDPRas-related protein SEC4/0.484
2nnqT4BFatty acid-binding protein, adipocyte/0.484
4nyiGNPGTPase HRas/0.484
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.482
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.482
4l9wGNPGTPase HRas/0.482
3vhxGTPADP-ribosylation factor 6/0.481
2msdGNPMHC class I alpha chain/0.479
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.479
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.479
3t4eNADQuinate/shikimate dehydrogenase/0.479
4djx0KQBeta-secretase 13.4.23.460.479
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.479
1a4rGNHCell division control protein 42 homolog/0.478
2bkuGTPGTP-binding nuclear protein Ran/0.478
2wo7ASVIsopenicillin N synthase1.21.3.10.478
5hpyGDPTransforming protein RhoA/0.478
4qxaGTPRas-related protein Rab-9A/0.477
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.476
3w3zGTPGTP-binding nuclear protein Ran/0.476
4iaq2GM5-hydroxytryptamine receptor 1B/0.476
4h9753SDihydrofolate reductase1.5.1.30.475
1ibrGNPGTP-binding nuclear protein Ran/0.474
3rabGNPRas-related protein Rab-3A/0.474
3vv8B02Beta-secretase 13.4.23.460.474
1bk0ACVIsopenicillin N synthase1.21.3.10.473
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.473
1yhnGTPRas-related protein Rab-7a/0.473
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.473
3a6pGTPGTP-binding nuclear protein Ran/0.473
1pd9CO4Dihydrofolate reductase1.5.1.30.472
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.472
3tozNADShikimate dehydrogenase (NADP(+))/0.472
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.472
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.471
2cl6CAGGTPase HRas/0.471
4iarERM5-hydroxytryptamine receptor 1B/0.471
4o2lGTPGTP-binding protein Rheb/0.471
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.471
1pqc444Oxysterols receptor LXR-beta/0.470
1vg8GNPRas-related protein Rab-7a/0.470
2c2aADPSensor histidine kinase/0.470
2rqfJH3Hemolymph juvenile hormone binding protein/0.470
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.470
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.470
2y6fM9FIsopenicillin N synthase1.21.3.10.469
3p74FMNPentaerythritol tetranitrate reductase/0.469
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.469
4cidANPEH domain-containing protein 2/0.469
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.469
1vyrFMNPentaerythritol tetranitrate reductase/0.468
1y9dTPPPyruvate oxidase1.2.3.30.468
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
3gonANPPhosphomevalonate kinase/0.467
3gwdNAPCyclohexanone monooxygenase/0.467
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.467
4lb2DM5Serum albumin/0.467
4r1lADPPhenylacetate-coenzyme A ligase/0.467
5dhgDGVNociceptin receptor/0.467
2wu5CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.466
2wu5CBESuccinate dehydrogenase cytochrome b556 subunit/0.466
3aosJH2Hemolymph juvenile hormone binding protein/0.466
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.466
4a81DXCMajor pollen allergen Bet v 1-A/0.466
4l8u9AZSerum albumin/0.466
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.465
1tkaN3TTransketolase 12.2.1.10.465
1yzqGNPRas-related protein Rab-6A/0.465
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.465
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.465
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
4frjDWBBeta-secretase 13.4.23.460.465
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.465
5iqiGNPBifunctional AAC/APH2.3.10.465
1n4pCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.464
1pq944BOxysterols receptor LXR-beta/0.464
2i62SAHNicotinamide N-methyltransferase2.1.1.10.464
3ekuCY9Actin-5C/0.464
1g17GNPRas-related protein SEC4/0.463
1n83CLRNuclear receptor ROR-alpha/0.463
1nw5SAMModification methylase RsrI2.1.1.720.463
1rx8NAPDihydrofolate reductase1.5.1.30.463
1s3uTQDDihydrofolate reductase1.5.1.30.463
1z0dGDPRas-related protein Rab-5C/0.463
3eg5GNPCell division control protein 42 homolog/0.463
1cxzGSPTransforming protein RhoA/0.462
1t91GTPRas-related protein Rab-7a/0.462
2w6oOA3Biotin carboxylase6.3.4.140.462
2zitNADExotoxin A2.4.2.360.462
3lqfNADGalactitol dehydrogenase/0.462
3ry2BTNStreptavidin/0.462
4ixd1HVIntegrin alpha-L/0.462
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1cqp803Integrin alpha-L/0.461
1dr3TAPDihydrofolate reductase1.5.1.30.461
2ffqGSPRas-related protein Rab-6B/0.461
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
2l0xGDPGTP-binding protein Rheb/0.461
2wbgLGSBeta-glucosidase A3.2.1.210.461
2wd8VGFPteridine reductase/0.461
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3wv9FEGHmd co-occurring protein HcgE/0.461
4q71FADBifunctional protein PutA/0.461
5agyGTBTau class glutathione S-transferase/0.461
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
1dr5NAPDihydrofolate reductase1.5.1.30.460
1kquBR4Phospholipase A2, membrane associated/0.460
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.460
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.460
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.460
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
1am4GNPCell division control protein 42 homolog/0.459
1db48INPhospholipase A2, membrane associated/0.459
1hb1OCVIsopenicillin N synthase1.21.3.10.459
2iviACWIsopenicillin N synthase1.21.3.10.459
2oegUPGUDP-glucose pyrophosphorylase/0.459
3b05FNRIsopentenyl-diphosphate delta-isomerase/0.459
3hpqAP5Adenylate kinase/0.459
3zeiAWHO-acetylserine sulfhydrylase/0.459
1rszDIHPurine nucleoside phosphorylase2.4.2.10.458
2c29NAPDihydroflavonol 4-reductase/0.458
2dhfDZFDihydrofolate reductase1.5.1.30.458
3n0hTOPDihydrofolate reductase1.5.1.30.458
3oafOAGDihydrofolate reductase1.5.1.30.458
4f31KAIGlutamate receptor 3/0.458
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.458
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.458
4hyvPEPPyruvate kinase 12.7.1.400.458
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.458
1vf2GTXGlutathione S-transferase 32.5.1.180.457
2bxqIMNSerum albumin/0.457
3c3xNAPEugenol synthase 11.1.1.3180.457
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.457
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.457
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.457
3uq9TBNPutative adenosine kinase/0.457
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.457
4j491J1Uncharacterized protein/0.457
4js0GNPCell division control protein 42 homolog/0.457
4rww2BALmo2692 protein/0.457
1cbqRE9Cellular retinoic acid-binding protein 2/0.456
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
1yhjR6CPyridoxal kinase2.7.1.350.456
1z7yAA5Cysteine synthase 12.5.1.470.456
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.456
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.456
3ea5GDPGTP-binding nuclear protein Ran/0.456
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.456
4krs1SXTankyrase-12.4.2.300.456
4tx9AMZPhosphoribosyl isomerase A/0.456
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
5k2aZMAAdenosine receptor A2a/0.456
1bzfTMQDihydrofolate reductase1.5.1.30.455
1oc1ASVIsopenicillin N synthase1.21.3.10.455
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.455
3wrlCAMCamphor 5-monooxygenase1.14.15.10.455
4ap0ADPKinesin-like protein KIF11/0.455
4g95OAGDihydrofolate reductase1.5.1.30.455
4h1e10JBeta-secretase 13.4.23.460.455
4mv1ADPBiotin carboxylase6.3.4.140.455
4n3l2FNProthrombin3.4.21.50.455
5iqaGNPBifunctional AAC/APH2.3.10.455
1f5fDHTSex hormone-binding globulin/0.454
1mewXMPInosine-5'-monophosphate dehydrogenase/0.454
1rx8FOLDihydrofolate reductase1.5.1.30.454
3bc1GNPRas-related protein Rab-27A/0.454
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3nbzGTPGTP-binding nuclear protein Ran/0.454
3p62FMNPentaerythritol tetranitrate reductase/0.454
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.454
4b7754MBeta-secretase 13.4.23.460.454
4m0lGDPTranslation initiation factor 2 subunit gamma/0.454
4xymCOAAcyl-CoA synthetase (NDP forming)/0.454
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.454
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.453
1ia3TQ5Dihydrofolate reductase1.5.1.30.453
1kt8ILPBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.453
1o9bNAIQuinate/shikimate dehydrogenase/0.453
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.453
1wklATPNucleoside diphosphate kinase/0.453
2qbnCAMCamphor 5-monooxygenase1.14.15.10.453
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3b78NADExotoxin A2.4.2.360.453
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.453
4frkDWDBeta-secretase 13.4.23.460.453
4loh1SYStimulator of interferon genes protein/0.453
4mitGTPRho-related protein racC/0.453
1jdvADNPurine nucleoside phosphorylase/0.452
1mvtDTMDihydrofolate reductase1.5.1.30.452
1txtCAAHMG-CoA synthase/0.452
2az3CDPNucleoside diphosphate kinase/0.452
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
3kz1GSPTransforming protein RhoA/0.452
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3ou2SAHSAM-dependent methyltransferase/0.452
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.452
3zoiM2WIsopenicillin N synthase1.21.3.10.452
4acuQN7Beta-secretase 13.4.23.460.452
4an4DUDPutative glycosyl transferase/0.452
4b0qGMFBeta-secretase 13.4.23.460.452
4b4w9L9Bifunctional protein FolD/0.452
4dc0NDPPutative ketoacyl reductase1.3.10.452
4ek1CAMCamphor 5-monooxygenase1.14.15.10.452
4i1nFOLDihydrofolate reductase1.5.1.30.452
5iqdGNPBifunctional AAC/APH2.3.10.452
1diuBDMDihydrofolate reductase1.5.1.30.451
1dr3HBIDihydrofolate reductase1.5.1.30.451
1draMTXDihydrofolate reductase1.5.1.30.451
1k22MELProthrombin3.4.21.50.451
1k5dGNPGTP-binding nuclear protein Ran/0.451
1mraAPGMandelate racemase/0.451
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.451
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.451
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.451
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.451
1wxjIPLTryptophan synthase alpha chain/0.451
2h15B19Carbonic anhydrase 24.2.1.10.451
2j9lATPH(+)/Cl(-) exchange transporter 5/0.451
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.451
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.451
2w6zL21Biotin carboxylase6.3.4.140.451
2xlpFADPutative flavin-containing monooxygenase/0.451
3dejRXCCaspase-33.4.22.560.451
3dkvAP5Adenylate kinase/0.451
4dc32FAPutative adenosine kinase/0.451
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.451
4f5dC2EStimulator of interferon genes protein/0.451
4jauADPSensor histidine kinase/0.451
4q0kGA3Phytohormone-binding protein/0.451
1klkPMDDihydrofolate reductase1.5.1.30.450
1nm6L86Prothrombin3.4.21.50.450
1zdwFLVPrenyltransferase/0.450
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2bxmIMNSerum albumin/0.450
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.450
3biz61EWee1-like protein kinase2.7.10.20.450
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.450
3fmoADPATP-dependent RNA helicase DDX19B3.6.4.130.450
3k7mFAD6-hydroxy-L-nicotine oxidase/0.450
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.450
3wyfGTPGTP-binding nuclear protein/0.450
4qbiAP5Adenylate kinase/0.450
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.450
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.449
1dr2TAPDihydrofolate reductase1.5.1.30.449
1ow3GDPTransforming protein RhoA/0.449
1qjfACSIsopenicillin N synthase1.21.3.10.449
1s3vTQDDihydrofolate reductase1.5.1.30.449
2f3rG5PGuanylate kinase2.7.4.80.449
2izhBTNStreptavidin/0.449
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.449
3f0aACOSpermidine N(1)-acetyltransferase/0.449
3fwgCAMCamphor 5-monooxygenase1.14.15.10.449
3gb4D3MDdmC/0.449
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3mpt1GKMitogen-activated protein kinase 14/0.449
3oesGNPGTPase RhebL1/0.449
3wrhCAMCamphor 5-monooxygenase1.14.15.10.449
4bfzZVZPantothenate kinase2.7.1.330.449
4kvgGTPRas-related protein Rap-1A/0.449
4nbwNADShort-chain dehydrogenase/reductase SDR/0.449
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.449
4opiFDAConserved Archaeal protein/0.449
4z28BTNHoefavidin/0.449
1dyhDZFDihydrofolate reductase1.5.1.30.448
1gtrATPGlutamine--tRNA ligase6.1.1.180.448
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.448
1rx1NAPDihydrofolate reductase1.5.1.30.448
1touB1VFatty acid-binding protein, adipocyte/0.448
1v8kANPKinesin-like protein KIF2C/0.448
2idkC2FGlycine N-methyltransferase2.1.1.200.448
2ok8FADFerredoxin--NADP reductase, apicoplast/0.448
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3fr4F8AFatty acid-binding protein, adipocyte/0.448
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.448
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1synF89Thymidylate synthase/0.447
1v35NAIEnoyl-ACP reductase/0.447
1xnjADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.447
1xtrGNPGTP-binding protein Rheb/0.447
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.447
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.447
2r2mI50Prothrombin3.4.21.50.447
2r6jNDPEugenol synthase 11.1.1.3180.447
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.447
3cwkREACellular retinoic acid-binding protein 2/0.447
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.447
3l0lHC3Nuclear receptor ROR-gamma/0.447
3w8fNAD3-hydroxybutyrate dehydrogenase/0.447
4ap3NAPSteroid monooxygenase/0.447
4bb3KKAIsopenicillin N synthase1.21.3.10.447
4e2yJHZMethyltransferase/0.447
4gutFADLysine-specific histone demethylase 1B10.447
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.447
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
5cccDDFDihydrofolate reductase1.5.1.30.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
5k2cZMAAdenosine receptor A2a/0.447
1dhrNADDihydropteridine reductase1.5.1.340.446
1kh3ANPArgininosuccinate synthase/0.446
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.446
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.446
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.446
1xe65FPPlasmepsin-23.4.23.390.446
2bdyUNBProthrombin3.4.21.50.446
2cv2GSUGlutamate--tRNA ligase6.1.1.170.446
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.446
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.446
2rtkGLLStreptavidin/0.446
2wlgSOPPolysialic acid O-acetyltransferase/0.446
2y66N04UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
3d7zGK5Mitogen-activated protein kinase 14/0.446
3k2fNKXCarbonic anhydrase 24.2.1.10.446
3kytHC2Nuclear receptor ROR-gamma/0.446
3mpeN2ACathepsin S3.4.22.270.446
3rgaILDEpoxide hydrolase LasB5.5.10.446
3sfdFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.446
3up0D7SaceDAF-12/0.446
4l7j1W2Beta-secretase 13.4.23.460.446
4o1mNADEnoyl-acyl carrier reductase/0.446
4tjy3GNTankyrase-22.4.2.300.446
4u0zAPCAdenosine monophosphate-protein transferase FICD2.7.7.n10.446
4xrbNDPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc/0.446
5stdUNNScytalone dehydratase4.2.1.940.446
1b8nIMGPurine nucleoside phosphorylase2.4.2.10.445
1ezvUQ6Cytochrome b/0.445
1h50FMNPentaerythritol tetranitrate reductase/0.445
1hvyD16Thymidylate synthase2.1.1.450.445
1mvsDTMDihydrofolate reductase1.5.1.30.445
1towCRZFatty acid-binding protein, adipocyte/0.445
1tslA15Thymidylate synthase/0.445
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
1ypkCCRProthrombin3.4.21.50.445
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.445
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3nj0PYVAbscisic acid receptor PYL2/0.445
3nr4PYVAbscisic acid receptor PYL2/0.445
3pndFADFAD:protein FMN transferase/0.445
3wagTYDGlycosyltransferase/0.445
3zkuHCVIsopenicillin N synthase1.21.3.10.445
4itfTFYVitamin D3 receptor/0.445
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
5iu86DZAdenosine receptor A2a/0.445
1blzACVIsopenicillin N synthase1.21.3.10.444
1dhiMTXDihydrofolate reductase1.5.1.30.444
1hdrNADDihydropteridine reductase1.5.1.340.444
1ia4TQ6Dihydrofolate reductase1.5.1.30.444
1id0ANPSensor protein PhoQ2.7.13.30.444
1ot7CHCBile acid receptor/0.444
1s4eADPGalactokinase/0.444
1t87CAMCamphor 5-monooxygenase1.14.15.10.444
1vi2NADQuinate/shikimate dehydrogenase/0.444
1ygjRMCPyridoxal kinase2.7.1.350.444
2a5kAZPReplicase polyprotein 1ab3.4.220.444
2aclL05Oxysterols receptor LXR-alpha/0.444
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.444
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2izfBTNStreptavidin/0.444
2wqpWQPPolysialic acid capsule biosynthesis protein SiaC/0.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
2ylrNAPPhenylacetone monooxygenase1.14.13.920.444
3fwjCAMCamphor 5-monooxygenase1.14.15.10.444
3gtsD3MDdmC/0.444
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.444
3s3vTOPDihydrofolate reductase1.5.1.30.444
3w0aDS5Vitamin D3 receptor/0.444
4briUNPEctonucleoside triphosphate diphosphohydrolase I/0.444
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.444
4giu636Anthranilate phosphoribosyltransferase/0.444
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.444
4i8vBHFCytochrome P450 1A11.14.14.10.444
4kbyC2EStimulator of interferon genes protein/0.444
4l1xNAPAldo-keto reductase family 1 member C2/0.444
4o25GTPGTP-binding protein Rheb/0.444
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.443
1ii6ADPKinesin-like protein KIF11/0.443
1m78NDPDihydrofolate reductase1.5.1.30.443
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
2a9z26AAdenosine kinase2.7.1.200.443
2gvdFKPAdenylate cyclase type 2/0.443
2gvdFKPAdenylate cyclase type 5/0.443
2hamC33Vitamin D3 receptor/0.443
2izkGLLStreptavidin/0.443
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.443
2vprTDCTetracycline repressor protein class H/0.443
2wlfACOPolysialic acid O-acetyltransferase/0.443
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3maaFKPAdenylate cyclase type 2/0.443
3maaFKPAdenylate cyclase type 5/0.443
3w8eNAD3-hydroxybutyrate dehydrogenase/0.443
4azy7F3Beta-secretase 13.4.23.460.443
4cf7ADPAdenylate kinase/0.443
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.443
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4i13FOLDihydrofolate reductase1.5.1.30.443
4lzwTHMUridine phosphorylase/0.443
4udqFAD5-(hydroxymethyl)furfural oxidase/0.443
5k2dZMAAdenosine receptor A2a/0.443
1a42BZUCarbonic anhydrase 24.2.1.10.442
1c5nESIProthrombin3.4.21.50.442
1d2sDHTSex hormone-binding globulin/0.442
1h51FMNPentaerythritol tetranitrate reductase/0.442
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.442
1mf0GDPAdenylosuccinate synthetase isozyme 1/0.442
1qoqIGPTryptophan synthase alpha chain/0.442
1xjjDGTVitamin B12-dependent ribonucleotide reductase/0.442
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2f6rACOBifunctional coenzyme A synthase/0.442
2gcpGSPRho-related GTP-binding protein RhoC/0.442
2he5NDPAldo-keto reductase family 1 member C211.1.10.442
2m56CAMCamphor 5-monooxygenase1.14.15.10.442
2mseGNPMHC class I alpha chain/0.442
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2q3fGNPRas-related GTP-binding protein D/0.442
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.442
2z4sADPChromosomal replication initiator protein DnaA/0.442
3atzFMNProstaglandin F2a synthase/0.442
3e5hGNPRas-related protein Rab-28/0.442
3ntz3TZDihydrofolate reductase1.5.1.30.442
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.442
3x2fNAIAdenosylhomocysteinase/0.442
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.442
4dpy2P0Mevalonate diphosphate decarboxylase/0.442
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.442
4imfSI3N-acetylneuraminate lyase/0.442
4mkgAP5Adenylate kinase/0.442
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.442
1aoeGW3Dihydrofolate reductase1.5.1.30.441
1mueCDDProthrombin3.4.21.50.441
1xduSFGAclacinomycin 10-hydroxylase RdmB4.1.10.441
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.441
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.441
2gpjFADSiderophore-interacting protein/0.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.441
3fhxPLPPyridoxal kinase2.7.1.350.441
3h4vNAPPteridine reductase 11.5.1.330.441
4acxS8ZBeta-secretase 13.4.23.460.441
4bfwZVWPantothenate kinase2.7.1.330.441
4dbzNDPPutative ketoacyl reductase1.3.10.441
4hmxFMNPyridoxamine 5'-phosphate oxidase/0.441
4k38SAMAnaerobic sulfatase-maturating enzyme1.8.980.441
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.441
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.441
4x5hFOLDihydrofolate reductase1.5.1.30.441
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.440
1jolFFODihydrofolate reductase1.5.1.30.440
1khrVIRStreptogramin A acetyltransferase2.3.10.440
1kt6RTLRetinol-binding protein 4/0.440
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.440
1n2bPAFPantothenate synthetase6.3.2.10.440
1pg3PRXAcetyl-coenzyme A synthetase/0.440
1szcCNANAD-dependent protein deacetylase HST23.5.10.440
1udaUFGUDP-glucose 4-epimerase5.1.3.20.440
2amb17HAndrogen receptor/0.440
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2feuCAMCamphor 5-monooxygenase1.14.15.10.440
2g78REACellular retinoic acid-binding protein 2/0.440
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xlrFADPutative flavin-containing monooxygenase/0.440
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.440
3phiNDPShikimate dehydrogenase (NADP(+))/0.440
3s7a684Dihydrofolate reductase1.5.1.30.440
3t3iGPWGlycogen phosphorylase, muscle form2.4.1.10.440
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
3up3XCAaceDAF-12/0.440
3zksWZVBeta-secretase 23.4.23.450.440
4a86H35Major pollen allergen Bet v 1-A/0.440
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.440
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.20.440
4h3g10QBeta-secretase 13.4.23.460.440
4l4fCAMCamphor 5-monooxygenase1.14.15.10.440
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4qtnNNRNicotinamide riboside transporter PnuC/0.440
5iqbGNPBifunctional AAC/APH2.3.10.440