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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.21.000
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.516
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.515
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.509
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.508
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.502
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.499
3w2sW2REpidermal growth factor receptor2.7.10.10.497
4bcmT7ZCyclin-dependent kinase 22.7.11.220.495
1pjkANPCasein kinase II subunit alpha2.7.11.10.491
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.483
5cvfATPCasein kinase II subunit alpha2.7.11.10.480
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.475
3at4CCKCasein kinase II subunit alpha2.7.11.10.473
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.472
4jia1K3Tyrosine-protein kinase JAK2/0.471
2fvdLIACyclin-dependent kinase 22.7.11.220.470
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3axwTIDCasein kinase II subunit alpha2.7.11.10.467
3lpbNVBTyrosine-protein kinase JAK2/0.467
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
5dt0SKEAurora kinase A2.7.11.10.467
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.466
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.464
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.464
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.464
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.461
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.460
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.460
2pvlP55Casein kinase II subunit alpha2.7.11.10.459
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.458
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.457
3uvqFS8Mitogen-activated protein kinase 14/0.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
2vu3LZECyclin-dependent kinase 22.7.11.220.455
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.455
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.453
3rkb12ZCyclin-dependent kinase 22.7.11.220.452
3u4uLNHCasein kinase II subunit alpha2.7.11.10.452
4aqc88ATyrosine-protein kinase JAK2/0.452
3q9xEMOCasein kinase II subunit alpha2.7.11.10.451
2wouZZFTGF-beta receptor type-12.7.11.300.450
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.450
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.449
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.449
2j0m4STFocal adhesion kinase 12.7.10.20.448
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.448
4hge15VTyrosine-protein kinase JAK2/0.448
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3vs3VSETyrosine-protein kinase HCK2.7.10.20.447
4jajXU1Aurora kinase A2.7.11.10.447
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.447
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.446
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.446
4g1wG1WMitogen-activated protein kinase 82.7.11.240.446
3zewSTUEphrin type-B receptor 42.7.10.10.445
3be9P04Casein kinase II subunit alpha2.7.11.10.444
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
5dr9SKEAurora kinase A2.7.11.10.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
2w05FRTCyclin-dependent kinase 22.7.11.220.443
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
4o0wADNAurora kinase A2.7.11.10.443
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.442
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3w33W19Epidermal growth factor receptor2.7.10.10.441
4anmWULCasein kinase II subunit alpha2.7.11.10.441
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3rak03ZCyclin-dependent kinase 22.7.11.220.440