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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.251.000
4bgg844Activin receptor type-12.7.11.300.536
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.531
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.526
1vjy460TGF-beta receptor type-12.7.11.300.525
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.524
3gxlQIGTGF-beta receptor type-12.7.11.300.524
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.524
3gubGUBDeath-associated protein kinase 12.7.11.10.523
3hmm855TGF-beta receptor type-12.7.11.300.519
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.519
3l8p0CEAngiopoietin-1 receptor2.7.10.10.518
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.517
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.516
4qmpDKISerine/threonine-protein kinase 242.7.11.10.516
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.515
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.515
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.512
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.511
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.509
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.508
1h1r6CPCyclin-dependent kinase 22.7.11.220.506
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.506
1di8DTQCyclin-dependent kinase 22.7.11.220.505
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.502
4hvh19RTyrosine-protein kinase JAK32.7.10.20.502
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.502
5drdATPAurora kinase A2.7.11.10.502
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.501
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.501
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.501
2xa4AZ5Tyrosine-protein kinase JAK2/0.501
2c6tDT5Cyclin-dependent kinase 22.7.11.220.500
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.500
3a60STURibosomal protein S6 kinase beta-12.7.11.10.499
4i22IREEpidermal growth factor receptor2.7.10.10.499
3be9P04Casein kinase II subunit alpha2.7.11.10.498
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.498
4hvi19STyrosine-protein kinase JAK32.7.10.20.498
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.497
4jbpYPHAurora kinase A2.7.11.10.497
1xjdSTUProtein kinase C theta type2.7.11.130.496
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.496
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.496
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.496
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.495
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.495
4xiwAZMCarbonic anhydrase, alpha type/0.495
5dt3ATPAurora kinase A2.7.11.10.495
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.494
2dwbANPAurora kinase A2.7.11.10.494
2pvnP63Casein kinase II subunit alpha2.7.11.10.494
3mtfA3FActivin receptor type-12.7.11.300.494
4wsqKSAAP2-associated protein kinase 12.7.11.10.493
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.492
2iw84SPCyclin-dependent kinase 22.7.11.220.492
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.492
3sheI85MAP kinase-activated protein kinase 32.7.11.10.492
4hvg19QTyrosine-protein kinase JAK32.7.10.20.492
5e8wSTUTGF-beta receptor type-12.7.11.300.492
1ol5ADPAurora kinase A2.7.11.10.490
2wotZZGTGF-beta receptor type-12.7.11.300.490
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.490
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.490
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.490
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.489
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.489
1bygSTUTyrosine-protein kinase CSK/0.488
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.488
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.487
3rmf20ZCyclin-dependent kinase 22.7.11.220.487
3s1dZIRCytokinin dehydrogenase 11.5.99.120.487
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.487
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.487
4jboWPHAurora kinase A2.7.11.10.487
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.486
2b7aIZATyrosine-protein kinase JAK2/0.485
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.485
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.484
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.484
3eb0DRKUncharacterized protein/0.484
3eljGS7Mitogen-activated protein kinase 82.7.11.240.484
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.484
4e4m0NHTyrosine-protein kinase JAK2/0.484
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.484
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.483
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.483
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.483
3k5uPFQAurora kinase A2.7.11.10.482
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.481
2iw94SPCyclin-dependent kinase 22.7.11.220.481
3zh8C58Protein kinase C iota type2.7.11.130.481
4fkv61KCyclin-dependent kinase 22.7.11.220.481
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.481
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.481
1eh4IC1Casein kinase I homolog 12.7.11.10.480
1rw8580TGF-beta receptor type-12.7.11.300.480
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.480
3r9dX6BCyclin-dependent kinase 22.7.11.220.480
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.480
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.480
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.479
2xikJ60Serine/threonine-protein kinase 252.7.11.10.479
4dgnLU2Casein kinase II subunit alpha2.7.11.10.479
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.479
3vs3VSETyrosine-protein kinase HCK2.7.10.20.478
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.478
4dgo0JWCasein kinase II subunit alpha2.7.11.10.478
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.478
5dr2ATPAurora kinase A2.7.11.10.478
1py5PY1TGF-beta receptor type-12.7.11.300.477
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.477
4aqc88ATyrosine-protein kinase JAK2/0.477
4fv7E94Mitogen-activated protein kinase 12.7.11.240.477
1aq1STUCyclin-dependent kinase 22.7.11.220.476
3pgqGY3Acetyl-CoA carboxylase/0.476
4dymIYZActivin receptor type-12.7.11.300.476
4hge15VTyrosine-protein kinase JAK2/0.476
2xneASHAurora kinase A2.7.11.10.475
3iok1P6Tyrosine-protein kinase JAK2/0.475
3rvg17PTyrosine-protein kinase JAK2/0.475
3w18N13Aurora kinase A2.7.11.10.475
4lopSB4Mitogen-activated protein kinase 14/0.475
4loqSB4Mitogen-activated protein kinase 14/0.475
1kkq471Peroxisome proliferator-activated receptor alpha/0.474
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
2pvhP19Casein kinase II subunit alpha2.7.11.10.473
4yuqKS1Calmodulin-like domain protein kinase/0.473
2h96893Mitogen-activated protein kinase 82.7.11.240.472
3rni21ZCyclin-dependent kinase 22.7.11.220.472
4dgmAGICasein kinase II subunit alpha2.7.11.10.472
4g170VNCasein kinase I isoform gamma-32.7.11.10.472
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.472
5dn3ATPAurora kinase A2.7.11.10.472
1h1s4SPCyclin-dependent kinase 22.7.11.220.471
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.471
1y0s331Peroxisome proliferator-activated receptor delta/0.471
3lfnA27Cyclin-dependent kinase 22.7.11.220.471
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.471
3t113T1Gag-Pol polyprotein3.4.23.160.471
1bdlIM1Gag-Pol polyprotein3.4.23.160.470
1gih1PUCyclin-dependent kinase 22.7.11.220.470
1k8y13PTryptophan synthase alpha chain/0.470
1m2qMNXCasein kinase II subunit alpha2.7.11.10.470
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.470
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.470
4k33ACPFibroblast growth factor receptor 32.7.10.10.470
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.469
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.469
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.469
2wouZZFTGF-beta receptor type-12.7.11.300.469
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.469
4c02TAKActivin receptor type-12.7.11.300.469
4jia1K3Tyrosine-protein kinase JAK2/0.469
5dr9SKEAurora kinase A2.7.11.10.469
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.468
1xkkFMMEpidermal growth factor receptor2.7.10.10.468
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.468
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.468
4eji0QACytochrome P450 2A131.14.14.10.468
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.468
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.468
6cp4CAMCamphor 5-monooxygenase1.14.15.10.468
1oi9N20Cyclin-dependent kinase 22.7.11.220.467
1udaUFGUDP-glucose 4-epimerase5.1.3.20.467
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.467
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.467
2eufLQQCyclin-dependent kinase 62.7.11.220.467
2wedPP6Penicillopepsin-13.4.23.200.467
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.467
4c62XWWTyrosine-protein kinase JAK2/0.467
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.466
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.466
4ivc1J6Tyrosine-protein kinase JAK1/0.466
4j5j478Gag-Pol polyprotein3.4.23.160.466
4jajXU1Aurora kinase A2.7.11.10.466
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.465
1xddAAYIntegrin alpha-L/0.465
3nieANPMitogen-activated protein kinase/0.465
4c58824Cyclin-G-associated kinase2.7.11.10.465
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.465
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.465
5dr6SKEAurora kinase A2.7.11.10.465
5e92ANPTGF-beta receptor type-22.7.11.300.465
1lf3EH5Plasmepsin-23.4.23.390.464
2hog710Serine/threonine-protein kinase Chk12.7.11.10.464
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.464
3livE16Protease/0.464
3r9oZ71Cyclin-dependent kinase 22.7.11.220.464
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.464
4anmWULCasein kinase II subunit alpha2.7.11.10.464
4lxhC1EAlpha/beta hydrolase fold/0.464
5e8xSTUTGF-beta receptor type-12.7.11.300.464
2rhgIGPTryptophan synthase alpha chain/0.463
2wecPP5Penicillopepsin-13.4.23.200.463
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.463
3uli1N3Cyclin-dependent kinase 22.7.11.220.463
3vf9477Tyrosine-protein kinase SYK2.7.10.20.463
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.463
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.463
4iwd1JCHepatocyte growth factor receptor2.7.10.10.463
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.463
2gtk208Peroxisome proliferator-activated receptor gamma/0.462
2x9fX9FEphrin type-B receptor 42.7.10.10.462
3gu83GUDeath-associated protein kinase 12.7.11.10.462
3w33W19Epidermal growth factor receptor2.7.10.10.462
4fnyI3KALK tyrosine kinase receptor2.7.10.10.462
4y93746Tyrosine-protein kinase/0.462
1bxoPP7Penicillopepsin-13.4.23.200.461
1mq4ADPAurora kinase A2.7.11.10.461
1pjcNADAlanine dehydrogenase/0.461
1xelUPGUDP-glucose 4-epimerase5.1.3.20.461
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.461
2w06FRVCyclin-dependent kinase 22.7.11.220.461
2xnbY8LCyclin-dependent kinase 22.7.11.220.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.461
3hx4ANPCalmodulin-domain protein kinase 1/0.461
3i60E86Mitogen-activated protein kinase 12.7.11.240.461
3oom507Activin receptor type-12.7.11.300.461
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.461
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.461
4fko20KCyclin-dependent kinase 22.7.11.220.461
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.461
4jqeANPCasein kinase II subunit alpha2.7.11.10.461
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.460
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.460
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.460
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.460
3l63CAMCamphor 5-monooxygenase1.14.15.10.460
3qu0X40Cyclin-dependent kinase 22.7.11.220.460
3rk507ZCyclin-dependent kinase 22.7.11.220.460
3uyt0CKCasein kinase I isoform delta2.7.11.10.460
4acm7YGCyclin-dependent kinase 22.7.11.220.460
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.460
4bgh3I6Cyclin-dependent kinase 22.7.11.220.460
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.460
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.460
4gmy0X5Tyrosine-protein kinase JAK2/0.460
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.459
1o76CAMCamphor 5-monooxygenase1.14.15.10.459
1ppjANYCytochrome b/0.459
1ppm0P1Penicillopepsin-13.4.23.200.459
2c5nCK8Cyclin-dependent kinase 22.7.11.220.459
2rh9IGPTryptophan synthase alpha chain/0.459
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.459
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.459
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.459
3w2cN15Aurora kinase A2.7.11.10.459
4eon1ROCyclin-dependent kinase 22.7.11.220.459
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.459
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
1m2rMNYCasein kinase II subunit alpha2.7.11.10.458
1oirHDYCyclin-dependent kinase 22.7.11.220.458
1om1IQACasein kinase II subunit alpha2.7.11.10.458
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2j14GNIPeroxisome proliferator-activated receptor delta/0.458
2qboCAMCamphor 5-monooxygenase1.14.15.10.458
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.458
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.458
3d7kD7KBenzaldehyde lyase/0.458
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.458
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.458
4eor4SPCyclin-dependent kinase 22.7.11.220.458
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4fkw62KCyclin-dependent kinase 22.7.11.220.458
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.458
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.457
1dirNADDihydropteridine reductase1.5.1.340.457
1ke6LS2Cyclin-dependent kinase 22.7.11.220.457
1oiuN76Cyclin-dependent kinase 22.7.11.220.457
2qblCAMCamphor 5-monooxygenase1.14.15.10.457
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.457
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.457
3ttjJBIMitogen-activated protein kinase 102.7.11.240.457
3w2sW2REpidermal growth factor receptor2.7.10.10.457
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
4nifANPMitogen-activated protein kinase 12.7.11.240.457
1urwI1PCyclin-dependent kinase 22.7.11.220.456
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.456
2ebaFADPutative glutaryl-CoA dehydrogenase/0.456
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.456
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.456
3sw418KCyclin-dependent kinase 22.7.11.220.456
3t3c017Gag-Pol polyprotein3.4.23.160.456
4bcoT6QCyclin-dependent kinase 22.7.11.220.456
4ez30S0Cyclin-dependent kinase 22.7.11.220.456
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.456
4ux9ANPMitogen-activated protein kinase 82.7.11.240.456
5e8ySTUTGF-beta receptor type-22.7.11.300.456
1kvuUPGUDP-glucose 4-epimerase5.1.3.20.455
1phePIYCamphor 5-monooxygenase1.14.15.10.455
1t85CAMCamphor 5-monooxygenase1.14.15.10.455
2bhhRYUCyclin-dependent kinase 22.7.11.220.455
2xmyCDKCyclin-dependent kinase 22.7.11.220.455
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.455
2z97CAMCamphor 5-monooxygenase1.14.15.10.455
3dogNNNCyclin-dependent kinase 22.7.11.220.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.455
4fv6E57Mitogen-activated protein kinase 12.7.11.240.455
4gk2L66Ephrin type-A receptor 32.7.10.10.455
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4q73FADBifunctional protein PutA/0.455
1m2pHNACasein kinase II subunit alpha2.7.11.10.454
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.454
1y91CT9Cyclin-dependent kinase 22.7.11.220.454
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.454
2q5g1FAPeroxisome proliferator-activated receptor delta/0.454
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.454
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.454
2zawCAMCamphor 5-monooxygenase1.14.15.10.454
2znnS44Peroxisome proliferator-activated receptor alpha/0.454
2znq401Peroxisome proliferator-activated receptor delta/0.454
3du8553Glycogen synthase kinase-3 beta2.7.11.260.454
3so9017Pol protein/0.454
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.454
3tvuB37Acetyl-CoA carboxylase/0.454
3wmxNADNAD dependent epimerase/dehydratase/0.454
4k5p1OSM1 family aminopeptidase3.4.110.454
4l4cCAMCamphor 5-monooxygenase1.14.15.10.454
4l4dCAMCamphor 5-monooxygenase1.14.15.10.454
4nr42LKCREB-binding protein/0.454
4ryvZEAProtein LlR18A/0.454
4uymVOR14-alpha sterol demethylase Cyp51B/0.454
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.453
2a94AP0L-lactate dehydrogenase1.1.1.270.453
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
3a9wNADNDP-sugar epimerase/0.453
3ekp478Gag-Pol polyprotein3.4.23.160.453
3eyhIZATyrosine-protein kinase JAK1/0.453
3le62BZCyclin-dependent kinase 22.7.11.220.453
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.453
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.453
4l4fCAMCamphor 5-monooxygenase1.14.15.10.453
5cp4CAMCamphor 5-monooxygenase1.14.15.10.453
1g5sI17Cyclin-dependent kinase 22.7.11.220.452
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.452
1rl8RITGag-Pol polyprotein3.4.23.160.452
1u54ACPActivated CDC42 kinase 1/0.452
1vbiNADMalate/L-lactate dehydrogenase family protein/0.452
2ci01CMLanosterol 14-alpha demethylase1.14.13.700.452
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.452
2zuiCAMCamphor 5-monooxygenase1.14.15.10.452
3hllI45Mitogen-activated protein kinase 14/0.452
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3oroAGSSerine/threonine protein kinase/0.452
3poz03PEpidermal growth factor receptor2.7.10.10.452
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.452
4erwSTUCyclin-dependent kinase 22.7.11.220.452
4fki09KCyclin-dependent kinase 22.7.11.220.452
4l4bCAMCamphor 5-monooxygenase1.14.15.10.452
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.452
4r20AERCytochrome P450 family 17 polypeptide 2/0.452
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
1e9hINRCyclin-dependent kinase 22.7.11.220.451
1hiiC20Gag-Pol polyprotein/0.451
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.451
1p4fDRGDeath-associated protein kinase 12.7.11.10.451
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.451
3cppCAMCamphor 5-monooxygenase1.14.15.10.451
3ctj320Hepatocyte growth factor receptor2.7.10.10.451
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.451
3qtzX42Cyclin-dependent kinase 22.7.11.220.451
3slz3TLPutative gag-pro-pol polyprotein/0.451
3t3r9PLCytochrome P450 2A61.14.130.451
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.451
3wrhCAMCamphor 5-monooxygenase1.14.15.10.451
4b4vL34Bifunctional protein FolD/0.451
4cp4CAMCamphor 5-monooxygenase1.14.15.10.451
4f650S9Fibroblast growth factor receptor 1/0.451
4fkj11KCyclin-dependent kinase 22.7.11.220.451
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.451
4kl9NDPDihydrofolate reductase1.5.1.30.451
4kwhNAPReductase homolog/0.451
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.451
4qmzB49Serine/threonine-protein kinase 242.7.11.10.451
1fvv107Cyclin-dependent kinase 22.7.11.220.450
1xe65FPPlasmepsin-23.4.23.390.450
1yvj4STTyrosine-protein kinase JAK32.7.10.20.450
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.450
2qo9ANPEphrin type-A receptor 32.7.10.10.450
2xyeCXGGag-Pol polyprotein/0.450
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.450
3qlrNDPDihydrofolate reductase1.5.1.30.450
3qtxX43Cyclin-dependent kinase 22.7.11.220.450
3rk909ZCyclin-dependent kinase 22.7.11.220.450
3s1h56ZCyclin-dependent kinase 22.7.11.220.450
3vvpBNUUncharacterized protein/0.450
4b7xNAPProbable oxidoreductase/0.450
4ejh0QACytochrome P450 2A131.14.14.10.450
4eok4SPCyclin-dependent kinase 22.7.11.220.450
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.450
4kbk1QGCasein kinase I isoform delta2.7.11.10.450
1dhrNADDihydropteridine reductase1.5.1.340.449
1dz6CAMCamphor 5-monooxygenase1.14.15.10.449
1e1xNW1Cyclin-dependent kinase 22.7.11.220.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
2a0cCK9Cyclin-dependent kinase 22.7.11.220.449
2b52D42Cyclin-dependent kinase 22.7.11.220.449
2gjlFMNNitronate monooxygenase1.13.12.160.449
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.449
2r3jSCJCyclin-dependent kinase 22.7.11.220.449
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.449
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.449
3h0aD30Peroxisome proliferator-activated receptor gamma/0.449
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.449
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.449
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.449
3zmmF9JTyrosine-protein kinase JAK2/0.449
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.449
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.449
4qgiROCGag-Pol polyprotein3.4.23.160.449
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5dosATPAurora kinase A2.7.11.10.449
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1pxlCK4Cyclin-dependent kinase 22.7.11.220.448
1t86CAMCamphor 5-monooxygenase1.14.15.10.448
2b1pAIZMitogen-activated protein kinase 102.7.11.240.448
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.448
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.448
2itpAEEEpidermal growth factor receptor2.7.10.10.448
2udpUPPUDP-glucose 4-epimerase5.1.3.20.448
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.448
3b6zCO7Enoyl reductase LovC10.448
3fwjCAMCamphor 5-monooxygenase1.14.15.10.448
3kfr3TLGag-Pol polyprotein/0.448
3litE15Protease/0.448
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.448
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.448
3t8oATPRhodopsin kinase/0.448
3unj0BXCyclin-dependent kinase 22.7.11.220.448
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.448
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.448
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.448
4oauADP2-5A-dependent ribonuclease3.1.260.448
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1k6pXN3Gag-Pol polyprotein3.4.23.160.447
1vikBAYGag-Pol polyprotein/0.447
1x2hLPALipoate-protein ligase A6.3.1.200.447
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.447
2feuCAMCamphor 5-monooxygenase1.14.15.10.447
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.447
2hcdBIVVitamin D3 receptor A/0.447
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.447
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.447
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.447
3s56ROCProtease/0.447
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.447
3t3q9PLCytochrome P450 2A61.14.130.447
3wecAUICytochrome P450/0.447
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.447
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.447
4c4jX21Dual specificity protein kinase TTK2.7.12.10.447
4ia3BIVVitamin D3 receptor A/0.447
4ikeADPAdenylate kinase/0.447
4ocvANPAminoglycoside phosphotransferase/0.447
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.446
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1zeoC01Peroxisome proliferator-activated receptor gamma/0.446
2g8yNADHydroxycarboxylate dehydrogenase B/0.446
3bhtMFRCyclin-dependent kinase 22.7.11.220.446
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3iqeH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.446
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.446
3unk0BYCyclin-dependent kinase 22.7.11.220.446
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.446
4dplNAPMalonyl-CoA reductase1.2.1.750.446
4enhFVXCholesterol 24-hydroxylase/0.446
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.446
4gub0Y4Casein kinase II subunit alpha2.7.11.10.446
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.446
1oiyN41Cyclin-dependent kinase 22.7.11.220.445
1pxmCK5Cyclin-dependent kinase 22.7.11.220.445
1udcUFMUDP-glucose 4-epimerase5.1.3.20.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.445
2x1nX1NCyclin-dependent kinase 22.7.11.220.445
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.445
2zdt46CMitogen-activated protein kinase 102.7.11.240.445
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.445
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.445
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.445
3nxe2NCProtease/0.445
3s79ASDAromatase1.14.14.140.445
3v9v21LPeroxisome proliferator-activated receptor gamma/0.445
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.445
4b4oNDPEpimerase family protein SDR39U1/0.445
4dpuAGSMevalonate diphosphate decarboxylase/0.445
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.445
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.445
5dt4ATPAurora kinase A2.7.11.10.445
5jscFADPutative acyl-CoA dehydrogenase/0.445
1gii1PUCyclin-dependent kinase 22.7.11.220.444
1oguST8Cyclin-dependent kinase 22.7.11.220.444
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.444
2bheBRYCyclin-dependent kinase 22.7.11.220.444
2cppCAMCamphor 5-monooxygenase1.14.15.10.444
2fy4COACholine O-acetyltransferase2.3.1.60.444
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2lfoGCHFatty acid-binding protein, liver/0.444
2om9AJAPeroxisome proliferator-activated receptor gamma/0.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
2qbmCAMCamphor 5-monooxygenase1.14.15.10.444
2znpK55Peroxisome proliferator-activated receptor delta/0.444
3ekv478Gag-Pol polyprotein3.4.23.160.444
3fwfCAMCamphor 5-monooxygenase1.14.15.10.444
3fwiCAMCamphor 5-monooxygenase1.14.15.10.444
3gdsVAL_TYR_TYR_PHESerine endoprotease DegS3.4.21.1070.444
3ibdCPZCytochrome P450 2B61.14.130.444
3lzs017Gag-Pol polyprotein3.4.23.160.444
3rk708ZCyclin-dependent kinase 22.7.11.220.444
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.444
3tz3B36Acetyl-CoA carboxylase/0.444
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.444
4c61LMMTyrosine-protein kinase JAK2/0.444
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.444
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.444
4hjoAQ4Epidermal growth factor receptor2.7.10.10.444
4jbqVX6Aurora kinase A2.7.11.10.444
4kba1QMCasein kinase I isoform delta2.7.11.10.444
4l49CAMCamphor 5-monooxygenase1.14.15.10.444
1ai9NDPDihydrofolate reductase1.5.1.30.443
1sh9RITGag-Pol polyprotein3.4.23.160.443
1u4dDBQActivated CDC42 kinase 1/0.443
2btrU73Cyclin-dependent kinase 22.7.11.220.443
2ejvNADL-threonine 3-dehydrogenase/0.443
2i0ePDSProtein kinase C beta type2.7.11.130.443
2nomDUTPoly(A) polymerase, putative/0.443
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.443
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
2y3sTIRTamL/0.443
3sm2478Putative gag-pro-pol polyprotein/0.443
3vt8YI3Vitamin D3 receptor/0.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4c9oCAMCytochrome P450/0.443
4ele31IDihydrofolate reductase/0.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.443
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.443
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.443
5auuLU2Death-associated protein kinase 12.7.11.10.443
1hvlA76Gag-Pol polyprotein/0.442
1ivp1ZKGag-Pol polyprotein/0.442
1nooCAHCamphor 5-monooxygenase1.14.15.10.442
1t7kBH0Gag-Pol polyprotein3.4.23.160.442
2a1mCAMCamphor 5-monooxygenase1.14.15.10.442
2a1nCAMCamphor 5-monooxygenase1.14.15.10.442
2np8CC3Aurora kinase A2.7.11.10.442
2w1hL0FCyclin-dependent kinase 22.7.11.220.442
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.442
3rak03ZCyclin-dependent kinase 22.7.11.220.442
3rkb12ZCyclin-dependent kinase 22.7.11.220.442
3t2vKKJPeptidoglycan recognition protein 1/0.442
3ufnROCGag-Pol polyprotein/0.442
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.442
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.442
4elf35IDihydrofolate reductase/0.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.442
5dp2NAPCurF/0.442
1gebCAMCamphor 5-monooxygenase1.14.15.10.441
1gqtACPRibokinase/0.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.441
1phgMYTCamphor 5-monooxygenase1.14.15.10.441
1w6hTITPlasmepsin-23.4.23.390.441
1xefATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.441
1xl5190Gag-Pol polyprotein3.4.23.160.441
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.441
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.441
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3at4CCKCasein kinase II subunit alpha2.7.11.10.441
3ictFADCoenzyme A disulfide reductase/0.441
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.441
3r8814FAnthranilate phosphoribosyltransferase/0.441
3r9hZ67Cyclin-dependent kinase 22.7.11.220.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
4fmxCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.441
4hnf16WCasein kinase I isoform delta2.7.11.10.441
4m10ICDProstaglandin G/H synthase 21.14.99.10.441
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4tuvCPZCytochrome P450 1191.140.441
4utdACPAurora kinase A2.7.11.10.441
4wkqIREEpidermal growth factor receptor2.7.10.10.441
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.441
1dr3HBIDihydrofolate reductase1.5.1.30.440
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1hdrNADDihydropteridine reductase1.5.1.340.440
1ke5LS1Cyclin-dependent kinase 22.7.11.220.440
1ol7ADPAurora kinase A2.7.11.10.440
1p9wANPType II secretion system protein E/0.440
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.440
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1w0xOLOCyclin-dependent kinase 22.7.11.220.440
1yrcCAMCamphor 5-monooxygenase1.14.15.10.440
1z0aGDPRas-related protein Rab-2A/0.440
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.440
2cciATPCyclin-dependent kinase 22.7.11.220.440
2of4979Tyrosine-protein kinase Lck2.7.10.20.440
2pvlP55Casein kinase II subunit alpha2.7.11.10.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.440
3gw9VNILanosterol 14-alpha-demethylase/0.440
3h0sB38Acetyl-CoA carboxylase/0.440
3lxiCAMCytochrome P450/0.440
3oriAGSSerine/threonine protein kinase/0.440
3pe6ZYHMonoglyceride lipase/0.440
3py0SU9Cyclin-dependent kinase 22.7.11.220.440
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
3sacAF8Protease/0.440
3t8vBTJM1 family aminopeptidase3.4.110.440
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
3wrlCAMCamphor 5-monooxygenase1.14.15.10.440
4a28ADPKinesin-like protein KIF11/0.440
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.440
4dc0NDPPutative ketoacyl reductase1.3.10.440
4eevL1XHepatocyte growth factor receptor2.7.10.10.440
4fkg4CKCyclin-dependent kinase 22.7.11.220.440
4fwjFADLysine-specific histone demethylase 1B10.440
4g160VMCasein kinase I isoform gamma-32.7.11.10.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.440
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.440
4hnc0UTMandelate racemase/0.440
4i02CMPcAMP-activated global transcriptional regulator CRP/0.440
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.440
4jazSTLPeroxisome proliferator-activated receptor gamma/0.440
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.440
4k5o1OTM1 family aminopeptidase3.4.110.440
4riyADPEpidermal growth factor receptor2.7.10.10.440
5av4GENDeath-associated protein kinase 12.7.11.10.440