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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l2g1V4Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l2g1V4Tankyrase-22.4.2.301.000
4bueJQFTankyrase-22.4.2.300.793
4l0t1V0Tankyrase-22.4.2.300.760
4buxF35Tankyrase-22.4.2.300.748
4hlh20DTankyrase-22.4.2.300.737
4bs4A64Tankyrase-22.4.2.300.693
4bus32FTankyrase-22.4.2.300.688
4buwF33Tankyrase-22.4.2.300.668
4l341VGTankyrase-22.4.2.300.639
4kzl20DTankyrase-22.4.2.300.637
4l2k1V8Tankyrase-22.4.2.300.636
4l0v1V1Tankyrase-22.4.2.300.634
4l0s1UZTankyrase-22.4.2.300.627
5aku29FTankyrase-22.4.2.300.621
4l0i1UWTankyrase-22.4.2.300.620
4hkkAGITankyrase-22.4.2.300.616
4bu908CTankyrase-22.4.2.300.615
4kzuA73Tankyrase-22.4.2.300.615
4hl515WTankyrase-22.4.2.300.609
4hlf15ZTankyrase-22.4.2.300.606
4iueAJ4Tankyrase-22.4.2.300.603
4buiW2ETankyrase-22.4.2.300.600
4hlm16STankyrase-22.4.2.300.600
4l2f1V3Tankyrase-22.4.2.300.595
4bufF36Tankyrase-22.4.2.300.594
4hlk431Tankyrase-22.4.2.300.594
4bud29FTankyrase-22.4.2.300.587
4l321VFTankyrase-22.4.2.300.584
4bj9UHBTankyrase-22.4.2.300.583
4l31F08Tankyrase-22.4.2.300.581
3p0pNNFTankyrase-22.4.2.300.578
4but31FTankyrase-22.4.2.300.578
4l33F70Tankyrase-22.4.2.300.574
4avwG18Tankyrase-22.4.2.300.571
4j22AJ7Tankyrase-22.4.2.300.571
4j21AJ6Tankyrase-22.4.2.300.569
4hmhF94Tankyrase-22.4.2.300.557
4tkg09LTankyrase-22.4.2.300.556
4hkiFLNTankyrase-22.4.2.300.543
4hknLU2Tankyrase-22.4.2.300.539
4krs1SXTankyrase-12.4.2.300.528
4bjbP34Tankyrase-22.4.2.300.527
4avuLDRTankyrase-22.4.2.300.522
4msk2C8Tankyrase-12.4.2.300.496
4pnmNU1Tankyrase-22.4.2.300.496
4l091URTankyrase-22.4.2.300.490
3mauPLRPutative sphingosine-1-phosphate lyase/0.477
1x8lOXRRetinol dehydratase/0.463
2bf7HBIPteridine reductase 11.5.1.330.459
4buv16ITankyrase-22.4.2.300.459
4j3lAJ5Tankyrase-22.4.2.300.459
1opbRETRetinol-binding protein 2/0.452
3qm4PN0Cytochrome P450 2D6/0.451
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.451
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.448
1zgbA1EAcetylcholinesterase3.1.1.70.446
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.443
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.441
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440