Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/1.000
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.606
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.599
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.591
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.582
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.581
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.576
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.571
4l2yXXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.570
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.568
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.565
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.563
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.560
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.560
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.560
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.558
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.557
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.556
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.553
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.551
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.550
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.549
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.549
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.546
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.545
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.539
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.538
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.534
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.534
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.534
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.531
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.531
4fa60TAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.530
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.529
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.526
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.526
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.522
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.516
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.515
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.512
4j6i1JVPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.512
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.511
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.507
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.506
3slkNDPPolyketide synthase extender module 2/0.499
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.496
1e9hINRCyclin-dependent kinase 22.7.11.220.494
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.493
3ibeL64Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.490
4dgo0JWCasein kinase II subunit alpha2.7.11.10.490
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.488
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.488
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.487
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.486
3at4CCKCasein kinase II subunit alpha2.7.11.10.486
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.483
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
1oiyN41Cyclin-dependent kinase 22.7.11.220.479
3zewSTUEphrin type-B receptor 42.7.10.10.478
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.478
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.477
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.476
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4uhrNGIAdenosine receptor A2a/0.475
1oi9N20Cyclin-dependent kinase 22.7.11.220.474
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.474
2qblCAMCamphor 5-monooxygenase1.14.15.10.474
3tnwF18Cyclin-dependent kinase 22.7.11.220.474
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.472
5k2bZMAAdenosine receptor A2a/0.471
3ielU5PRibonuclease TTHA02523.10.470
1nooCAHCamphor 5-monooxygenase1.14.15.10.469
2c4g514Cyclin-dependent kinase 22.7.11.220.469
2qo9ANPEphrin type-A receptor 32.7.10.10.469
2yeiXQIHeat shock protein HSP 90-alpha/0.469
3fwfCAMCamphor 5-monooxygenase1.14.15.10.469
1t86CAMCamphor 5-monooxygenase1.14.15.10.468
2ydoADNAdenosine receptor A2a/0.468
3axwTIDCasein kinase II subunit alpha2.7.11.10.468
5k2aZMAAdenosine receptor A2a/0.468
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.467
3njoPYVAbscisic acid receptor PYR1/0.467
2vd5BI8Myotonin-protein kinase2.7.11.10.466
2ydvNECAdenosine receptor A2a/0.466
4c62XWWTyrosine-protein kinase JAK2/0.466
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.465
1uy9PU6Heat shock protein HSP 90-alpha/0.464
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
2vx07X7Ephrin type-B receptor 42.7.10.10.463
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
1h1pCMGCyclin-dependent kinase 22.7.11.220.462
1iwiCAMCamphor 5-monooxygenase1.14.15.10.462
3be9P04Casein kinase II subunit alpha2.7.11.10.462
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.461
3cisATPUniversal stress protein Rv2623/0.461
3q9xEMOCasein kinase II subunit alpha2.7.11.10.461
3qakUKAAdenosine receptor A2a/0.461
1og5SWFCytochrome P450 2C9/0.460
3r9dX6BCyclin-dependent kinase 22.7.11.220.460
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4gu94GUFocal adhesion kinase 12.7.10.20.460
5aaaVGHALK tyrosine kinase receptor2.7.10.10.460
2a1nCAMCamphor 5-monooxygenase1.14.15.10.459
2i40BLZCyclin-dependent kinase 22.7.11.220.459
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.459
2p4yC03Peroxisome proliferator-activated receptor gamma/0.458
3qdd94MHeat shock protein HSP 90-alpha/0.458
4jia1K3Tyrosine-protein kinase JAK2/0.458
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.458
1uy7PU4Heat shock protein HSP 90-alpha/0.457
4dscA8SAbscisic acid receptor PYL3/0.457
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
1h1r6CPCyclin-dependent kinase 22.7.11.220.455
1m2pHNACasein kinase II subunit alpha2.7.11.10.455
2bujSTUSerine/threonine-protein kinase 16/0.455
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.455
4bcqTJFCyclin-dependent kinase 22.7.11.220.455
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
4hyu1BKMitogen-activated protein kinase 82.7.11.240.455
1dz8CAMCamphor 5-monooxygenase1.14.15.10.454
1uy6PU3Heat shock protein HSP 90-alpha/0.454
1uyfPU1Heat shock protein HSP 90-alpha/0.454
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.454
3amyAGICasein kinase II subunit alpha2.7.11.10.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.454
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.454
4qnaX11Serine/threonine-protein kinase 242.7.11.10.454
5k2cZMAAdenosine receptor A2a/0.454
2w98P1ZProstaglandin reductase 21.3.1.480.453
2yn8STUEphrin type-B receptor 42.7.10.10.453
3vt7VDXVitamin D3 receptor/0.453
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.453
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.453
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
5uviZMAAdenosine receptor A2a/0.453
1iwjCAMCamphor 5-monooxygenase1.14.15.10.452
1t88CAMCamphor 5-monooxygenase1.14.15.10.452
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.452
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.452
4l4bCAMCamphor 5-monooxygenase1.14.15.10.452
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
5iua6DXAdenosine receptor A2a/0.452
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.451
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.451
2b55D31Cyclin-dependent kinase 22.7.11.220.451
2vr1ATFBiotin carboxylase6.3.4.140.451
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.451
4ek1CAMCamphor 5-monooxygenase1.14.15.10.451
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.451
5auwQUEDeath-associated protein kinase 12.7.11.10.451
2i0ePDSProtein kinase C beta type2.7.11.130.450
2yee2ECHeat shock protein HSP 90-alpha/0.450
2z97CAMCamphor 5-monooxygenase1.14.15.10.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.450
5e8ySTUTGF-beta receptor type-22.7.11.300.450
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.449
2in6839Wee1-like protein kinase2.7.10.20.449
2qboCAMCamphor 5-monooxygenase1.14.15.10.449
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.449
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.449
3wrmCAMCamphor 5-monooxygenase1.14.15.10.449
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.449
4gevCB3Thymidylate synthase/0.449
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.449
5iu86DZAdenosine receptor A2a/0.449
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.448
2c3qGTXGlutathione S-transferase theta-12.5.1.180.448
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2z2w770Wee1-like protein kinase2.7.10.20.448
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.448
5av4GENDeath-associated protein kinase 12.7.11.10.448
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
1x8lOXRRetinol dehydratase/0.447
2cppCAMCamphor 5-monooxygenase1.14.15.10.447
2v7a627Tyrosine-protein kinase ABL12.7.10.20.447
3ft8MOJHeat shock protein HSP 90-alpha/0.447
3itzP66Mitogen-activated protein kinase 14/0.447
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.447
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.447
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
2iw94SPCyclin-dependent kinase 22.7.11.220.446
2vwz7X6Ephrin type-B receptor 42.7.10.10.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
4grb0XGCasein kinase II subunit alpha2.7.11.10.446
4izy1J2Mitogen-activated protein kinase 82.7.11.240.446
4l49CAMCamphor 5-monooxygenase1.14.15.10.446
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.446
5cu6ATPCasein kinase II subunit alpha2.7.11.10.446
1dz4CAMCamphor 5-monooxygenase1.14.15.10.445
1uyiPUZHeat shock protein HSP 90-alpha/0.445
2vx17X8Ephrin type-B receptor 42.7.10.10.445
3at3ATKCasein kinase II subunit alpha2.7.11.10.445
3fwjCAMCamphor 5-monooxygenase1.14.15.10.445
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.445
3wrjCAMCamphor 5-monooxygenase1.14.15.10.445
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.445
1n71COAAac(6')-Ii protein/0.444
1urwI1PCyclin-dependent kinase 22.7.11.220.444
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
2npnSAMPutative cobalamin synthesis related protein/0.444
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2w05FRTCyclin-dependent kinase 22.7.11.220.444
2x6dX6DAurora kinase A2.7.11.10.444
2z3uCRRCytochrome P450/0.444
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.444
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.444
3oroAGSSerine/threonine protein kinase/0.444
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.444
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.444
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.444
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4zhqACPTubulin tyrosine ligase/0.444
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.443
2zb45OPProstaglandin reductase 21.3.1.480.443
3b7dCNIGlutamate receptor 2/0.443
3s7a684Dihydrofolate reductase1.5.1.30.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.443
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.443
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.443
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.442
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2hw2RFPRifampin ADP-ribosyl transferase/0.442
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3o0iP54Heat shock protein HSP 90-alpha/0.442
3rmf20ZCyclin-dependent kinase 22.7.11.220.442
3wv9FEGHmd co-occurring protein HcgE/0.442
3zh8C58Protein kinase C iota type2.7.11.130.442
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.442
4l4aCAMCamphor 5-monooxygenase1.14.15.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1uy8PU5Heat shock protein HSP 90-alpha/0.441
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.441
2j0j4STFocal adhesion kinase 12.7.10.20.441
2m56CAMCamphor 5-monooxygenase1.14.15.10.441
3nnuEDBMitogen-activated protein kinase 14/0.441
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.441
3ral04ZCyclin-dependent kinase 22.7.11.220.441
3wrhCAMCamphor 5-monooxygenase1.14.15.10.441
4bcnT9NCyclin-dependent kinase 22.7.11.220.441
4l4cCAMCamphor 5-monooxygenase1.14.15.10.441
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.440
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.440
1ndzFR5Adenosine deaminase3.5.4.40.440
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.440
1umlFR4Adenosine deaminase3.5.4.40.440
1v7aFRCAdenosine deaminase3.5.4.40.440
1vyw292Cyclin-dependent kinase 22.7.11.220.440
1y0s331Peroxisome proliferator-activated receptor delta/0.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
2vwx7X4Ephrin type-B receptor 42.7.10.10.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440
3fu83DMLaccase-11.10.3.20.440
3gwnFADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
3n0tOPYDipeptidyl peptidase 23.4.14.20.440
3ns2PYVAbscisic acid receptor PYL2/0.440
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.440
4gub0Y4Casein kinase II subunit alpha2.7.11.10.440
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.440
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.440
5aabVGHALK tyrosine kinase receptor2.7.10.10.440