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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kzl20DTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kzl20DTankyrase-22.4.2.301.000
4l2f1V3Tankyrase-22.4.2.300.813
4l0v1V1Tankyrase-22.4.2.300.772
4l0s1UZTankyrase-22.4.2.300.747
4bu908CTankyrase-22.4.2.300.740
4hlf15ZTankyrase-22.4.2.300.728
4buuF38Tankyrase-22.4.2.300.721
4bufF36Tankyrase-22.4.2.300.701
4buiW2ETankyrase-22.4.2.300.693
5aku29FTankyrase-22.4.2.300.682
4buxF35Tankyrase-22.4.2.300.666
4bus32FTankyrase-22.4.2.300.663
4l2g1V4Tankyrase-22.4.2.300.646
4hlm16STankyrase-22.4.2.300.645
4l0t1V0Tankyrase-22.4.2.300.644
4bueJQFTankyrase-22.4.2.300.643
4l341VGTankyrase-22.4.2.300.642
4hlh20DTankyrase-22.4.2.300.640
4l0i1UWTankyrase-22.4.2.300.640
4hl515WTankyrase-22.4.2.300.625
4iueAJ4Tankyrase-22.4.2.300.625
4l321VFTankyrase-22.4.2.300.617
4avwG18Tankyrase-22.4.2.300.615
3p0pNNFTankyrase-22.4.2.300.613
4hkkAGITankyrase-22.4.2.300.607
4l2k1V8Tankyrase-22.4.2.300.607
4hmhF94Tankyrase-22.4.2.300.601
4bud29FTankyrase-22.4.2.300.596
4hknLU2Tankyrase-22.4.2.300.590
4buwF33Tankyrase-22.4.2.300.588
4hkiFLNTankyrase-22.4.2.300.584
4l31F08Tankyrase-22.4.2.300.584
4l091URTankyrase-22.4.2.300.583
4bs4A64Tankyrase-22.4.2.300.578
3u9y09LTankyrase-22.4.2.300.577
4j21AJ6Tankyrase-22.4.2.300.574
4l33F70Tankyrase-22.4.2.300.572
4bj9UHBTankyrase-22.4.2.300.560
4krs1SXTankyrase-12.4.2.300.556
4buv16ITankyrase-22.4.2.300.545
4pnrG18Tankyrase-22.4.2.300.532
4pnmNU1Tankyrase-22.4.2.300.517
4tkg09LTankyrase-22.4.2.300.512
4msk2C8Tankyrase-12.4.2.300.507
4bjbP34Tankyrase-22.4.2.300.506
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.482
4j3lAJ5Tankyrase-22.4.2.300.480
3tqcADPPantothenate kinase/0.474
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.467
4tjy3GNTankyrase-22.4.2.300.464
4avuLDRTankyrase-22.4.2.300.463
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.456
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.455
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.453
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.452
2bf7HBIPteridine reductase 11.5.1.330.450
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
2vprTDCTetracycline repressor protein class H/0.449
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.448
4b1e6T6Beta-secretase 13.4.23.460.445
4b68NAPL-ornithine N(5)-monooxygenase/0.445
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.444
1zdwFLVPrenyltransferase/0.442
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.442
3h3qH13Collagen type IV alpha-3-binding protein/0.441
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.440