sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4ksp	1SU	Serine/threonine-protein kinase B-raf	2.7.11.1

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4ksp	1SU	Serine/threonine-protein kinase B-raf	2.7.11.1	1.000
4fc0	0T2	Serine/threonine-protein kinase B-raf	2.7.11.1	0.558
5hi2	BAX	Serine/threonine-protein kinase B-raf	2.7.11.1	0.520
4c8b	0LI	Receptor-interacting serine/threonine-protein kinase 2	2.7.11.1	0.495
3hv5	R24	Mitogen-activated protein kinase 14	/	0.454
3efl	706	Vascular endothelial growth factor receptor 2	2.7.10.1	0.453
2oiq	STI	Proto-oncogene tyrosine-protein kinase Src	2.7.10.2	0.443
2og8	1N8	Tyrosine-protein kinase Lck	2.7.10.2	0.442