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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kqsIPEFarnesyl pyrophosphate synthase2.5.1.101.000
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.788
3ez3IPEFarnesyl pyrophosphate synthase, putative/0.534
4nkeIPEFarnesyl pyrophosphate synthase2.5.1.100.534
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.533
3ldwIPEFarnesyl pyrophosphate synthase, putative/0.511
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.507
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.498
3rbmB73Farnesyl pyrophosphate synthase, putative/0.481
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.481
3rywK9HFarnesyl pyrophosphate synthase, putative/0.476
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.469
3krfIPEGeranyl diphosphate synthase large subunit/0.465
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.463
3ryeUNRFarnesyl pyrophosphate synthase2.5.1.100.463
1rqjIPEFarnesyl diphosphate synthase2.5.1.100.456
1rqjRISFarnesyl diphosphate synthase2.5.1.100.452
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.451
3krfDSTGeranyl diphosphate synthase large subunit/0.446
4lfgIPEPutative geranyltranstransferase/0.445
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.440