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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kip1R9Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4kip1R9Mitogen-activated protein kinase 14/1.000
3fklFKLMitogen-activated protein kinase 14/0.610
4aa4QC0Mitogen-activated protein kinase 14/0.586
4aacAAVMitogen-activated protein kinase 14/0.582
3iphG11Mitogen-activated protein kinase 14/0.561
3nww3NWMitogen-activated protein kinase 14/0.554
3fln3FNMitogen-activated protein kinase 14/0.553
4kiq1RAMitogen-activated protein kinase 14/0.547
3flwFLWMitogen-activated protein kinase 14/0.544
2rg5279Mitogen-activated protein kinase 14/0.538
3dt1P40Mitogen-activated protein kinase 14/0.536
3flzFLZMitogen-activated protein kinase 14/0.536
3hl7I47Mitogen-activated protein kinase 14/0.530
3mpt1GKMitogen-activated protein kinase 14/0.530
4kin1M8Mitogen-activated protein kinase 14/0.525
3fmh533Mitogen-activated protein kinase 14/0.522
3s4qNK0Mitogen-activated protein kinase 14/0.517
3fi4FI4Mitogen-activated protein kinase 14/0.515
4aa5NQBMitogen-activated protein kinase 14/0.514
2balPQAMitogen-activated protein kinase 14/0.513
3ocgOCGMitogen-activated protein kinase 14/0.512
3flyFLYMitogen-activated protein kinase 14/0.510
3l8xN4DMitogen-activated protein kinase 14/0.510
2rg6287Mitogen-activated protein kinase 14/0.509
4lopSB4Mitogen-activated protein kinase 14/0.509
3hllI45Mitogen-activated protein kinase 14/0.508
3mvl38PMitogen-activated protein kinase 14/0.496
2qd9LGFMitogen-activated protein kinase 14/0.495
3mvm39PMitogen-activated protein kinase 14/0.483
3u8w09JMitogen-activated protein kinase 14/0.483
3fmkFMKMitogen-activated protein kinase 14/0.482
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.480
3gc9B45Mitogen-activated protein kinase 112.7.11.240.470
3gfeP37Mitogen-activated protein kinase 14/0.469
3fskRO6Mitogen-activated protein kinase 14/0.467
4looSB4Mitogen-activated protein kinase 14/0.464
1phePIYCamphor 5-monooxygenase1.14.15.10.463
3uibSB2Putative mitogen-activated protein kinase/0.463
2ghlLIBMitogen-activated protein kinase 14/0.462
2y6o1N1Ephrin type-A receptor 42.7.10.10.461
3w33W19Epidermal growth factor receptor2.7.10.10.460
3fl4FL4Mitogen-activated protein kinase 14/0.457
3mpaSB2Mitogen-activated protein kinase 14/0.456
3ds6A17Mitogen-activated protein kinase 14/0.455
3roc29AMitogen-activated protein kinase 14/0.455
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.453
4eh60ONMitogen-activated protein kinase 14/0.452
3bv3P39Mitogen-activated protein kinase 14/0.451
3hvcGG5Mitogen-activated protein kinase 14/0.451
4hnf16WCasein kinase I isoform delta2.7.11.10.451
1ywrLI9Mitogen-activated protein kinase 14/0.448
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.448
2ftoCB3Thymidylate synthase/0.446
3fknFKNMitogen-activated protein kinase 14/0.446
2qo9ANPEphrin type-A receptor 32.7.10.10.445
1xddAAYIntegrin alpha-L/0.444
2zb1GK4Mitogen-activated protein kinase 14/0.444
1zyjBI5Mitogen-activated protein kinase 14/0.443
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4l4dCAMCamphor 5-monooxygenase1.14.15.10.443
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.440
3itzP66Mitogen-activated protein kinase 14/0.440