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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k6mSAHGenome polyprotein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4k6mSAHGenome polyprotein/1.000
2pxaSAHGenome polyprotein2.7.7.480.612
2xbmSAHGenome polyprotein/0.553
2p41SAHGenome polyprotein/0.548
3p8z36AGenome polyprotein2.1.1.560.541
4ctkSAMGenome polyprotein/0.529
2px5SAHGenome polyprotein2.7.7.480.523
4ctjSAMGenome polyprotein/0.511
3eluSAMMethyltransferase/0.503
3eldSFGMethyltransferase/0.497
2wa2SAMGenome polyprotein/0.496
2oxtSAMGenome polyprotein/0.489
5jjrSAHGenome polyprotein/0.484
3lkzSFGGenome polyprotein/0.477
3p8zSAHGenome polyprotein2.1.1.560.473
2px2SAHGenome polyprotein2.7.7.480.465
5jjsSAHGenome polyprotein/0.459
3elySAHMethyltransferase/0.447