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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.21.000
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.581
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.565
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.559
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.549
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.540
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.509
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.508
3vs3VSETyrosine-protein kinase HCK2.7.10.20.496
3w2sW2REpidermal growth factor receptor2.7.10.10.485
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.463
3w33W19Epidermal growth factor receptor2.7.10.10.459
3vs1VSATyrosine-protein kinase HCK2.7.10.20.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441