sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4k0b	SAM	S-adenosylmethionine synthase

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4k0b	SAM	S-adenosylmethionine synthase	/	1.000
4l2z	S7M	S-adenosylmethionine synthase	/	0.628
3tm0	ANP	Aminoglycoside 3'-phosphotransferase	2.7.1.95	0.448
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.448
4wh3	ATP	N-acetylhexosamine 1-kinase	2.7.1.162	0.444
3fr2	8CA	Fatty acid-binding protein, adipocyte	/	0.443
1kh2	ATP	Argininosuccinate synthase	/	0.441
1mbz	IOT	Carboxyethyl-arginine beta-lactam-synthase	6.3.3.4	0.441
3coy	53H	Pantothenate synthetase	6.3.2.1	0.441
1djq	ADP	Trimethylamine dehydrogenase	1.5.8.2	0.440