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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4jvr1MTE3 ubiquitin-protein ligase Mdm26.3.21.000
4jwr1MYE3 ubiquitin-protein ligase Mdm26.3.20.529
4erf0R3E3 ubiquitin-protein ligase Mdm26.3.20.500
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.20.479
1u3dFADCryptochrome-1/0.455
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.440