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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.101.000
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.588
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.564
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.543
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.526
4q23RISFarnesyl pyrophosphate synthase2.5.1.100.519
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.514
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.504
3iczPB6Farnesyl pyrophosphate synthase/0.483
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.481
3ldwZOLFarnesyl pyrophosphate synthase, putative/0.465
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.453
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.451
1zdwFLVPrenyltransferase/0.450
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.450
3tfn2CJDehydrosqualene synthase/0.450
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.450
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.448
3wsbRWZFarnesyltransferase, putative/0.448
3nynSGVG protein-coupled receptor kinase 62.7.11.160.447
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.444