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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4js0GNPCell division control protein 42 homolog

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4js0GNPCell division control protein 42 homolog/1.000
3eg5GNPCell division control protein 42 homolog/0.611
1kmqGNPTransforming protein RhoA/0.574
2gcpGSPRho-related GTP-binding protein RhoC/0.573
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.545
1cxzGSPTransforming protein RhoA/0.543
1xtsGTPGTP-binding protein Rheb/0.538
1xtrGNPGTP-binding protein Rheb/0.537
1a2bGSPTransforming protein RhoA/0.533
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.532
1s1cGNPTransforming protein RhoA/0.531
1m7bGTPRho-related GTP-binding protein RhoE/0.530
3kz1GSPTransforming protein RhoA/0.527
5dhaGNPGTP-binding nuclear protein Ran/0.511
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.510
5hpyGDPTransforming protein RhoA/0.508
3a58GNPGTP-binding protein RHO1/0.507
4mitGTPRho-related protein racC/0.504
1yhnGTPRas-related protein Rab-7a/0.500
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.500
3v4fGNPGTPase HRas/0.496
1t91GTPRas-related protein Rab-7a/0.495
3th5GNPRas-related C3 botulinum toxin substrate 1/0.494
4nyjGNPGTPase HRas/0.494
1zbdGTPRas-related protein Rab-3A/0.492
3e5hGNPRas-related protein Rab-28/0.492
4xoiGTPTransforming protein RhoA/0.491
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.488
3lbnGNPGTPase HRas/0.487
1g17GNPRas-related protein SEC4/0.486
1z2cGNPRho-related GTP-binding protein RhoC/0.483
3w3zGTPGTP-binding nuclear protein Ran/0.482
3bbpGTPRas-related protein Rab-6A/0.481
4nyiGNPGTPase HRas/0.480
1e96GTPRas-related C3 botulinum toxin substrate 1/0.479
1gwnGTPRho-related GTP-binding protein RhoE/0.476
1ibrGNPGTP-binding nuclear protein Ran/0.474
1yzqGNPRas-related protein Rab-6A/0.474
2zetGTPRas-related protein Rab-27B/0.472
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.472
3a6pGTPGTP-binding nuclear protein Ran/0.471
3oivGNPGTPase HRas/0.471
2ffqGSPRas-related protein Rab-6B/0.469
3nbzGTPGTP-binding nuclear protein Ran/0.468
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.468
5b2zGNPGTPase HRas/0.468
3rabGNPRas-related protein Rab-3A/0.467
2gilGTPRas-related protein Rab-6A/0.466
3tklGTPRas-related protein Rab-1A/0.465
3ddcGNPGTPase HRas/0.464
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.463
4lhwGNPRas-related protein Rab-8A/0.463
4o25GTPGTP-binding protein Rheb/0.462
1zc3GNPRas-related protein Ral-A/0.461
3oesGNPGTPase RhebL1/0.461
3oiuGNPGTPase HRas/0.461
4kvgGTPRas-related protein Rap-1A/0.461
4cymGCPRas-related protein Rab-32/0.459
1vg8GNPRas-related protein Rab-7a/0.455
3rs5GNPGTPase HRas/0.455
1zc4GNPRas-related protein Ral-A/0.454
3i3sGNPGTPase HRas/0.453
4dltGNPGTPase HRas/0.446
4rkfGNPRas-related protein Rab-3/0.446
5jljGNPGTP-binding nuclear protein Ran/0.445
3ea5GDPGTP-binding nuclear protein Ran/0.443
2clsGTPRho-related GTP-binding protein Rho6/0.442
3bc1GNPRas-related protein Rab-27A/0.442
2c5lGTPGTPase HRas/0.441
2fe4GDPRas-related protein Rab-6B/0.441
4dsoGSPGTPase KRas/0.441