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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j57FADThioredoxin reductase 21.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4j57FADThioredoxin reductase 21.8.1.91.000
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.504
2hqmFADGlutathione reductase1.8.1.70.501
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.487
1tytFADTrypanothione reductase1.8.1.120.480
1fecFADTrypanothione reductase1.8.1.120.469
1bzlFADTrypanothione reductase1.8.1.120.468
4dnaFADProbable glutathione reductase/0.464
4la1FADThioredoxin glutathione reductase/0.463
1gerFADGlutathione reductase1.8.1.70.457
4nevFADTrypanothione reductase/0.454
4b1bFADThioredoxin reductase1.8.1.90.452
2jk6FADTrypanothione reductase/0.446
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.440