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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j56FADThioredoxin reductase 21.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4j56FADThioredoxin reductase 21.8.1.91.000
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.521
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.518
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.506
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.503
1bzlFADTrypanothione reductase1.8.1.120.491
1grhFADGlutathione reductase, mitochondrial1.8.1.70.490
1febFADTrypanothione reductase1.8.1.120.481
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.479
2hqmFADGlutathione reductase1.8.1.70.475
1gerFADGlutathione reductase1.8.1.70.473
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.467
3grsFADGlutathione reductase, mitochondrial1.8.1.70.464
4nevFADTrypanothione reductase/0.464
4la1FADThioredoxin glutathione reductase/0.457
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.450
1fecFADTrypanothione reductase1.8.1.120.448
4dnaFADProbable glutathione reductase/0.442
2v6oFADThioredoxin glutathione reductase/0.440
4jq9FADDihydrolipoyl dehydrogenase/0.440