sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.686 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.599 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.598 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.592 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.578 | |
| 3qly | 55V | Uncharacterized protein | / | 0.578 | |
| 2zza | FOL | Dihydrofolate reductase | / | 0.576 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.571 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.570 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.567 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 3eej | 53R | Uncharacterized protein | / | 0.560 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.559 | |
| 3eem | 53V | Uncharacterized protein | / | 0.557 | |
| 3eel | 53T | Uncharacterized protein | / | 0.556 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.556 | |
| 3eek | 53S | Uncharacterized protein | / | 0.554 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.550 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.548 | |
| 3cse | N22 | Uncharacterized protein | / | 0.548 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.545 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.544 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.541 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.541 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.539 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.539 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.537 | |
| 1dg7 | WRB | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.532 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.531 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.531 | |
| 4nx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.530 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.529 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.528 | |
| 1ia1 | TQ3 | Dihydrofolate reductase | 1.5.1.3 | 0.527 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 3frd | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.522 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 1m78 | CLZ | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.520 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 3qfx | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.518 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.516 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.515 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.515 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3ia4 | MTX | Dihydrofolate reductase | / | 0.510 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.508 | |
| 3fy9 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.507 | |
| 3tq9 | MTX | Dihydrofolate reductase | / | 0.504 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3srr | Q20 | Dihydrofolate reductase | 1.5.1.3 | 0.501 | |
| 3jw5 | TOP | Dihydrofolate reductase | / | 0.500 | |
| 2w3v | TOP | Dihydrofolate reductase | / | 0.499 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3frf | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.497 | |
| 3srw | Q27 | Dihydrofolate reductase | 1.5.1.3 | 0.497 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.496 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.495 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3srq | Q19 | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4kjj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.489 | |
| 4nx6 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.489 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.488 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.488 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.487 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3fyw | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.484 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.483 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.483 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.483 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.481 | |
| 7dfr | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3fre | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.477 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.477 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.476 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.476 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.474 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.473 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.473 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.472 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.471 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.471 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.471 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2w9g | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.469 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.469 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.468 | |
| 3fyv | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1zdw | FLV | Prenyltransferase | / | 0.467 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.467 | |
| 4fgh | 0U6 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.467 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.466 | |
| 2ogi | GDP | Uncharacterized protein | / | 0.466 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.465 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.465 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.465 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.465 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.464 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.463 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3sh2 | 5DR | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.462 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.462 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.461 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.461 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3m08 | RAR | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3qyo | Q24 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.461 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.460 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.460 | |
| 3bgq | VX2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.460 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.460 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.459 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.459 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.459 | |
| 3k45 | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.459 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.459 | |
| 4p66 | MTX | Dihydrofolate reductase | / | 0.459 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.458 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.458 | |
| 1fml | RTL | Retinol dehydratase | / | 0.457 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.457 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.457 | |
| 3fra | I2H | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 3sa2 | 7DR | Dihydrofolate reductase | / | 0.457 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.457 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.457 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.457 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.457 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.457 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1rx2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.456 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.456 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.456 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.456 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.455 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.455 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 3up3 | XCA | aceDAF-12 | / | 0.455 | |
| 3uq9 | TBN | Putative adenosine kinase | / | 0.455 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.454 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.454 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.454 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.454 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.454 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.454 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.454 | |
| 1dtn | APG | Mandelate racemase | / | 0.453 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.453 | |
| 3ql3 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.453 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.453 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.453 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1ikw | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.452 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.452 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.452 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.452 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.452 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.451 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.451 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.451 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.451 | |
| 4k0y | 1OA | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.451 | |
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 0.450 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.450 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.450 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4fgg | 0U5 | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.450 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.450 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.449 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.449 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.449 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
| 4m7v | RAR | Dihydrofolate reductase | / | 0.449 | |
| 5kje | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dyr | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.448 | |
| 2oby | NAP | Quinone oxidoreductase PIG3 | 1 | 0.448 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.448 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.448 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3uwl | FOZ | Thymidylate synthase | / | 0.448 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.448 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.448 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.447 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.447 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3r33 | 6ME | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.447 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.447 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.447 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.446 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.446 | |
| 3dol | GWI | Pol protein | / | 0.446 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.446 | |
| 3sru | Q26 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4ezl | 0SE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.445 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.445 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.445 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4h6p | FMN | Chromate reductase | / | 0.445 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.445 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.444 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.444 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.444 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.444 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4mf1 | 29Y | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.444 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2bgl | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.443 | |
| 2i0e | PDS | Protein kinase C beta type | 2.7.11.13 | 0.443 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.443 | |
| 3k2h | LYA | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3zux | TCH | Transporter | / | 0.443 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.443 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.443 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 2xiz | XIZ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.442 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3h1j | SMA | Cytochrome b | / | 0.442 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.442 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.442 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.442 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.442 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.442 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.441 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 2kce | D16 | Thymidylate synthase | / | 0.441 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.441 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.441 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.441 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.441 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.441 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.441 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.441 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.441 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3m7r | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3up0 | D7S | aceDAF-12 | / | 0.440 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 3zvv | XAZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.440 | |
| 4twp | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.440 |