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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ivb1J5Tyrosine-protein kinase JAK1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ivb1J5Tyrosine-protein kinase JAK1/1.000
4e4n0NLTyrosine-protein kinase JAK1/0.601
4i5cC5ITyrosine-protein kinase JAK1/0.549
4e6d0NUTyrosine-protein kinase JAK2/0.544
4ei40Q2Tyrosine-protein kinase JAK1/0.532
4hge15VTyrosine-protein kinase JAK2/0.517
4fk60UJTyrosine-protein kinase JAK1/0.505
4aqc88ATyrosine-protein kinase JAK2/0.501
4f081RSTyrosine-protein kinase JAK2/0.501
4ivd15TTyrosine-protein kinase JAK1/0.496
4e5w0NTTyrosine-protein kinase JAK1/0.483
3lpbNVBTyrosine-protein kinase JAK2/0.482
4e6q0NVTyrosine-protein kinase JAK2/0.476
2vu3LZECyclin-dependent kinase 22.7.11.220.475
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.475
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.473
4bgh3I6Cyclin-dependent kinase 22.7.11.220.472
4k771Q4Tyrosine-protein kinase JAK1/0.471
4ji91M3Tyrosine-protein kinase JAK2/0.468
4ehzJAKTyrosine-protein kinase JAK1/0.463
2fvdLIACyclin-dependent kinase 22.7.11.220.462
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.460
4fv6E57Mitogen-activated protein kinase 12.7.11.240.459
3s1h56ZCyclin-dependent kinase 22.7.11.220.458
3be9P04Casein kinase II subunit alpha2.7.11.10.453
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.452
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4ii5ADPCyclin-dependent kinase 22.7.11.220.450
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.449
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
3ezvEZVCyclin-dependent kinase 22.7.11.220.448
3qxpX64Cyclin-dependent kinase 22.7.11.220.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.447
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.447
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.446
1yvj4STTyrosine-protein kinase JAK32.7.10.20.445
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4wsqKSAAP2-associated protein kinase 12.7.11.10.444
1g5sI17Cyclin-dependent kinase 22.7.11.220.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3eb0DRKUncharacterized protein/0.443
4e4l0NHTyrosine-protein kinase JAK1/0.443
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.442
1y91CT9Cyclin-dependent kinase 22.7.11.220.441
3rkb12ZCyclin-dependent kinase 22.7.11.220.441
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.441
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.440
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.440