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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.623
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.621
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.617
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.599
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.591
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
5iqiGNPBifunctional AAC/APH2.3.10.505
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.501
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.494
4iaiADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
5iqeGNPBifunctional AAC/APH2.3.10.483
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
5iqgGDPBifunctional AAC/APH2.3.10.475
4orkGDPBifunctional AAC/APH2.3.10.474
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.469
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
4iadADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4ysjADPCalmodulin-like domain protein kinase/0.465
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3fhiANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.458
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4ehzJAKTyrosine-protein kinase JAK1/0.457
4s33ANPMitogen-activated protein kinase 12.7.11.240.457
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3c4zADPRhodopsin kinase/0.454
4xw6ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
5bylGCPBifunctional AAC/APH2.3.10.453
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.452
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
5iqdGNPBifunctional AAC/APH2.3.10.445
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
1okkGCPSignal recognition particle protein/0.443
1okkGCPSignal recognition particle receptor FtsY/0.443
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.441
4ji91M3Tyrosine-protein kinase JAK2/0.440