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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i7fNVEGag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4i7fNVEGag-Pol polyprotein2.7.7.491.000
1rt2TNKGag-Pol polyprotein2.7.7.490.550
1c1bGCAGag-Pol polyprotein2.7.7.490.535
1klmSPPGag-Pol polyprotein2.7.7.490.532
3ffi3OBGag-Pol polyprotein2.7.7.490.518
3m8qDJZGag-Pol polyprotein2.7.7.490.472
3i0rRT3Gag-Pol polyprotein2.7.7.490.468
1fk9EFZGag-Pol polyprotein2.7.7.490.464
1ep4S11Gag-Pol polyprotein2.7.7.490.462
3lamKRPGag-Pol polyprotein2.7.7.490.448