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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i22IREEpidermal growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4i22IREEpidermal growth factor receptor2.7.10.11.000
1eh4IC1Casein kinase I homolog 12.7.11.10.518
4riyADPEpidermal growth factor receptor2.7.10.10.517
3w2sW2REpidermal growth factor receptor2.7.10.10.516
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.511
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.510
1pmn984Mitogen-activated protein kinase 102.7.11.240.500
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.499
3w33W19Epidermal growth factor receptor2.7.10.10.499
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.498
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.498
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.495
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.493
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.492
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.491
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.491
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.490
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.490
2wotZZGTGF-beta receptor type-12.7.11.300.487
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.486
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.485
3mtfA3FActivin receptor type-12.7.11.300.485
4fob0USALK tyrosine kinase receptor2.7.10.10.485
1u54ACPActivated CDC42 kinase 1/0.482
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.482
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.482
3ttjJBIMitogen-activated protein kinase 102.7.11.240.482
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.482
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.481
4zseANPEpidermal growth factor receptor2.7.10.10.481
3poz03PEpidermal growth factor receptor2.7.10.10.478
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.478
4yuqKS1Calmodulin-like domain protein kinase/0.478
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.477
3r9dX6BCyclin-dependent kinase 22.7.11.220.477
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.474
5e8wSTUTGF-beta receptor type-12.7.11.300.474
1u4dDBQActivated CDC42 kinase 1/0.473
3vryB43Tyrosine-protein kinase HCK2.7.10.20.473
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.473
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.472
2xa4AZ5Tyrosine-protein kinase JAK2/0.471
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.471
4bgg844Activin receptor type-12.7.11.300.471
4c02TAKActivin receptor type-12.7.11.300.471
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.471
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.470
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.470
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.470
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.470
1xjdSTUProtein kinase C theta type2.7.11.130.469
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4erwSTUCyclin-dependent kinase 22.7.11.220.469
4kba1QMCasein kinase I isoform delta2.7.11.10.469
1xkkFMMEpidermal growth factor receptor2.7.10.10.468
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.468
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.468
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.468
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.468
1vjy460TGF-beta receptor type-12.7.11.300.466
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.466
2w05FRTCyclin-dependent kinase 22.7.11.220.465
3vs1VSATyrosine-protein kinase HCK2.7.10.20.465
4c4g7RODual specificity protein kinase TTK2.7.12.10.465
3uyt0CKCasein kinase I isoform delta2.7.11.10.464
3vs3VSETyrosine-protein kinase HCK2.7.10.20.464
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.464
4hvh19RTyrosine-protein kinase JAK32.7.10.20.464
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.464
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.462
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
3gubGUBDeath-associated protein kinase 12.7.11.10.461
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.461
4fod0UVALK tyrosine kinase receptor2.7.10.10.461
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
4dgnLU2Casein kinase II subunit alpha2.7.11.10.460
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.460
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.460
2gs7ANPEpidermal growth factor receptor2.7.10.10.459
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2h96893Mitogen-activated protein kinase 82.7.11.240.458
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.458
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.458
4hjoAQ4Epidermal growth factor receptor2.7.10.10.457
4y93746Tyrosine-protein kinase/0.457
1bygSTUTyrosine-protein kinase CSK/0.456
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.456
4c4h7RODual specificity protein kinase TTK2.7.12.10.456
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.455
3a60STURibosomal protein S6 kinase beta-12.7.11.10.455
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
3w18N13Aurora kinase A2.7.11.10.455
2xp2VGHALK tyrosine kinase receptor2.7.10.10.454
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.454
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4b99R4LMitogen-activated protein kinase 72.7.11.240.454
4kb81QNCasein kinase I isoform delta2.7.11.10.454
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.453
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
4hni16WCasein kinase I isoform epsilon2.7.11.10.453
5cnnANPEpidermal growth factor receptor2.7.10.10.453
1m2pHNACasein kinase II subunit alpha2.7.11.10.452
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.452
4fv9E71Mitogen-activated protein kinase 12.7.11.240.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.451
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.451
3ttiKBIMitogen-activated protein kinase 102.7.11.240.450
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.450
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
2ittAEEEpidermal growth factor receptor2.7.10.10.449
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.449
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4fnyI3KALK tyrosine kinase receptor2.7.10.10.449
4hge15VTyrosine-protein kinase JAK2/0.449
4jboWPHAurora kinase A2.7.11.10.449
4kbk1QGCasein kinase I isoform delta2.7.11.10.449
4wkqIREEpidermal growth factor receptor2.7.10.10.449
4y95746Tyrosine-protein kinase/0.449
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.448
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.448
4jbpYPHAurora kinase A2.7.11.10.448
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2excJNKMitogen-activated protein kinase 102.7.11.240.447
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
3w2rW2REpidermal growth factor receptor2.7.10.10.447
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.447
4hnf16WCasein kinase I isoform delta2.7.11.10.447
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.446
2znnS44Peroxisome proliferator-activated receptor alpha/0.446
3bu5ATPInsulin receptor2.7.10.10.446
3hmm855TGF-beta receptor type-12.7.11.300.446
2iw84SPCyclin-dependent kinase 22.7.11.220.445
2pvnP63Casein kinase II subunit alpha2.7.11.10.445
3nynSGVG protein-coupled receptor kinase 62.7.11.160.445
3oom507Activin receptor type-12.7.11.300.445
4anmWULCasein kinase II subunit alpha2.7.11.10.445
4fuxE75Mitogen-activated protein kinase 12.7.11.240.445
4k33ACPFibroblast growth factor receptor 32.7.10.10.445
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.444
2o0uC0MMitogen-activated protein kinase 102.7.11.240.444
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.444
3t2zFADSulfide-quinone reductase/0.444
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.444
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.443
2iw94SPCyclin-dependent kinase 22.7.11.220.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.442
4jia1K3Tyrosine-protein kinase JAK2/0.442
5awmANPStress-activated protein kinase JNK2.7.11.240.442
2j0m4STFocal adhesion kinase 12.7.10.20.441
2wouZZFTGF-beta receptor type-12.7.11.300.441
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.441
3k5uPFQAurora kinase A2.7.11.10.441
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
4jbqVX6Aurora kinase A2.7.11.10.441
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.440
2q5g1FAPeroxisome proliferator-activated receptor delta/0.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.440
3kf7L9GMitogen-activated protein kinase 14/0.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
4aotGW8Serine/threonine-protein kinase 102.7.11.10.440
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.440
4qmpDKISerine/threonine-protein kinase 242.7.11.10.440
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.440