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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i1iNADMalate dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4i1iNADMalate dehydrogenase/1.000
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.536
2a92NAIL-lactate dehydrogenase/0.534
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.518
2aa3AP0L-lactate dehydrogenase/0.517
3d4pNADL-lactate dehydrogenase 11.1.1.270.501
4rlsNAIL-lactate dehydrogenase A chain1.1.1.270.487
3gvhNADMalate dehydrogenase/0.481
2x0iNAIMalate dehydrogenase/0.479
1wziNDPMalate dehydrogenase/0.473
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.472
4uunNAIL-lactate dehydrogenase/0.470
1ez4NADL-lactate dehydrogenase1.1.1.270.465
1uxkNADMalate dehydrogenase/0.465
1guyNADMalate dehydrogenase/0.461
1b8uNADMalate dehydrogenase/0.458
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.457
1ur5NADMalate dehydrogenase/0.454
2ldbNADL-lactate dehydrogenase1.1.1.270.453
1gv0NADMalate dehydrogenase/0.447
1wzeNADMalate dehydrogenase/0.445
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.444
3wswNADL-lactate dehydrogenase/0.442
1b8vNADMalate dehydrogenase/0.441
1bdmNAXMalate dehydrogenase/0.441