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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hvi19STyrosine-protein kinase JAK32.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hvi19STyrosine-protein kinase JAK32.7.10.21.000
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.558
1yvj4STTyrosine-protein kinase JAK32.7.10.20.511
3lpbNVBTyrosine-protein kinase JAK2/0.507
4ji91M3Tyrosine-protein kinase JAK2/0.495
4i5cC5ITyrosine-protein kinase JAK1/0.491
4aqc88ATyrosine-protein kinase JAK2/0.487
4e6q0NVTyrosine-protein kinase JAK2/0.480
4jia1K3Tyrosine-protein kinase JAK2/0.478
4bbfO19Tyrosine-protein kinase JAK2/0.477
4e4n0NLTyrosine-protein kinase JAK1/0.475
2ckeIQUDeath-associated protein kinase 2/0.473
4hge15VTyrosine-protein kinase JAK2/0.472
4bbe3O4Tyrosine-protein kinase JAK2/0.470
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.469
5cvfATPCasein kinase II subunit alpha2.7.11.10.460
1jklANPDeath-associated protein kinase 12.7.11.10.456
4f081RSTyrosine-protein kinase JAK2/0.456
1ig1ANPDeath-associated protein kinase 12.7.11.10.454
5av2KMPDeath-associated protein kinase 12.7.11.10.447
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.445
4dgnLU2Casein kinase II subunit alpha2.7.11.10.445
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.444