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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hni16WCasein kinase I isoform epsilon2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hni16WCasein kinase I isoform epsilon2.7.11.11.000
3uyt0CKCasein kinase I isoform delta2.7.11.10.483
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4kbk1QGCasein kinase I isoform delta2.7.11.10.464
3w33W19Epidermal growth factor receptor2.7.10.10.462
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.448
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
3mtfA3FActivin receptor type-12.7.11.300.442
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.442
3q9xEMOCasein kinase II subunit alpha2.7.11.10.440
4hnf16WCasein kinase I isoform delta2.7.11.10.440