scPDB - Distribution of Cavity Similarity values of 4hmh entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4hmh	F94	Tankyrase-2	2.4.2.30

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4hmh	F94	Tankyrase-2	2.4.2.30	1.000
4iue	AJ4	Tankyrase-2	2.4.2.30	0.650
4hlh	20D	Tankyrase-2	2.4.2.30	0.634
4kzl	20D	Tankyrase-2	2.4.2.30	0.634
4hl5	15W	Tankyrase-2	2.4.2.30	0.633
4hlf	15Z	Tankyrase-2	2.4.2.30	0.633
4bue	JQF	Tankyrase-2	2.4.2.30	0.624
4l2f	1V3	Tankyrase-2	2.4.2.30	0.622
4l0i	1UW	Tankyrase-2	2.4.2.30	0.620
4hlm	16S	Tankyrase-2	2.4.2.30	0.619
4l0v	1V1	Tankyrase-2	2.4.2.30	0.617
4l32	1VF	Tankyrase-2	2.4.2.30	0.617
4bus	32F	Tankyrase-2	2.4.2.30	0.614
4l0t	1V0	Tankyrase-2	2.4.2.30	0.610
4l33	F70	Tankyrase-2	2.4.2.30	0.610
4buf	F36	Tankyrase-2	2.4.2.30	0.609
4bux	F35	Tankyrase-2	2.4.2.30	0.609
5aku	29F	Tankyrase-2	2.4.2.30	0.605
4l2k	1V8	Tankyrase-2	2.4.2.30	0.601
4l2g	1V4	Tankyrase-2	2.4.2.30	0.596
3p0p	NNF	Tankyrase-2	2.4.2.30	0.592
4l09	1UR	Tankyrase-2	2.4.2.30	0.591
4bs4	A64	Tankyrase-2	2.4.2.30	0.589
4l34	1VG	Tankyrase-2	2.4.2.30	0.587
4buw	F33	Tankyrase-2	2.4.2.30	0.586
4hkn	LU2	Tankyrase-2	2.4.2.30	0.585
4j3l	AJ5	Tankyrase-2	2.4.2.30	0.577
4krs	1SX	Tankyrase-1	2.4.2.30	0.575
4l0s	1UZ	Tankyrase-2	2.4.2.30	0.568
4pnr	G18	Tankyrase-2	2.4.2.30	0.567
4j21	AJ6	Tankyrase-2	2.4.2.30	0.561
4avw	G18	Tankyrase-2	2.4.2.30	0.556
4hki	FLN	Tankyrase-2	2.4.2.30	0.550
4buv	16I	Tankyrase-2	2.4.2.30	0.542
4bjb	P34	Tankyrase-2	2.4.2.30	0.529
4avu	LDR	Tankyrase-2	2.4.2.30	0.527
4tkg	09L	Tankyrase-2	2.4.2.30	0.509
4pnm	NU1	Tankyrase-2	2.4.2.30	0.506
4msk	2C8	Tankyrase-1	2.4.2.30	0.502
4tjy	3GN	Tankyrase-2	2.4.2.30	0.491
2dw4	FAD	Lysine-specific histone demethylase 1A	1	0.485
1lnm	DTX	Bilin-binding protein	/	0.477
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.475
2ejz	SAH	Diphthine synthase	/	0.470
4gv0	8ME	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.466
4k4e	K4E	Tankyrase-1	2.4.2.30	0.466
2fm5	M99	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.464
4i9i	1DY	Tankyrase-1	2.4.2.30	0.464
4dvi	2IW	Tankyrase-1	2.4.2.30	0.462
3tky	N7I	(Iso)eugenol O-methyltransferase	2.1.1.146	0.461
1c7o	PPG	Hemolysin	/	0.457
4o9c	COA	Acetyl-CoA acetyltransferase	2.3.1.9	0.456
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.455
3wi2	P98	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.455
4l6s	1WQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.455
3hmv	HBT	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.454
1dfo	PLG	Serine hydroxymethyltransferase	2.1.2.1	0.452
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.450
1nqu	RDL	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.449
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.449
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.449
3qpo	PFR	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.448
3zj7	C1K	Strictosidine-O-beta-D-glucosidase	3.2.1.105	0.447
4ia0	5BB	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.447
1jtq	LY3	Thymidylate synthase	/	0.446
3eku	CY9	Actin-5C	/	0.446
3uic	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.445
1gky	5GP	Guanylate kinase	2.7.4.8	0.444
3g1r	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.444
4g56	SAH	Protein arginine N-methyltransferase 5	/	0.444
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.444
1wp4	NDP	3-hydroxyisobutyrate dehydrogenase	/	0.443
3dop	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.443
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.443
3imx	B84	Glucokinase	2.7.1.2	0.443
1fvp	FMA	Non-fluorescent flavoprotein	/	0.442
1zkn	IBM	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.442
2jgs	BTN	Avidin	/	0.442
3sqz	COA	Putative hydroxymethylglutaryl-CoA synthase	/	0.442
1oyn	ROL	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
3h4v	DVP	Pteridine reductase 1	1.5.1.33	0.441
4br0	AU1	Ectonucleoside triphosphate diphosphohydrolase 2	/	0.441
4ggz	BTN	Bll1558 protein	/	0.441
4lwx	MU2	Ribosome inactivating protein	/	0.441
1sqi	869	4-hydroxyphenylpyruvate dioxygenase	/	0.440
4hlk	431	Tankyrase-2	2.4.2.30	0.440
4jbs	P52	Endoplasmic reticulum aminopeptidase 2	3.4.11	0.440
4li7	1XP	Tankyrase-1	2.4.2.30	0.440