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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hl515WTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hl515WTankyrase-22.4.2.301.000
4hlf15ZTankyrase-22.4.2.300.666
4l0i1UWTankyrase-22.4.2.300.656
4buxF35Tankyrase-22.4.2.300.651
4iueAJ4Tankyrase-22.4.2.300.649
4l0t1V0Tankyrase-22.4.2.300.646
4l2k1V8Tankyrase-22.4.2.300.645
4kzl20DTankyrase-22.4.2.300.635
4l0s1UZTankyrase-22.4.2.300.629
4bueJQFTankyrase-22.4.2.300.625
4hkkAGITankyrase-22.4.2.300.622
4hlh20DTankyrase-22.4.2.300.621
4hlm16STankyrase-22.4.2.300.619
4l33F70Tankyrase-22.4.2.300.619
4l2g1V4Tankyrase-22.4.2.300.618
4bud29FTankyrase-22.4.2.300.614
4bu908CTankyrase-22.4.2.300.611
4j22AJ7Tankyrase-22.4.2.300.611
3p0pNNFTankyrase-22.4.2.300.610
4l0v1V1Tankyrase-22.4.2.300.609
4l2f1V3Tankyrase-22.4.2.300.607
4l31F08Tankyrase-22.4.2.300.607
4buuF38Tankyrase-22.4.2.300.606
4l341VGTankyrase-22.4.2.300.604
4hmhF94Tankyrase-22.4.2.300.603
4kzuA73Tankyrase-22.4.2.300.597
5aku29FTankyrase-22.4.2.300.596
4bus32FTankyrase-22.4.2.300.593
4buiW2ETankyrase-22.4.2.300.592
4l321VFTankyrase-22.4.2.300.588
4but31FTankyrase-22.4.2.300.580
4j21AJ6Tankyrase-22.4.2.300.580
4hkiFLNTankyrase-22.4.2.300.574
4pnrG18Tankyrase-22.4.2.300.570
4avwG18Tankyrase-22.4.2.300.564
4bs4A64Tankyrase-22.4.2.300.551
4buwF33Tankyrase-22.4.2.300.548
4tkg09LTankyrase-22.4.2.300.530
4krs1SXTankyrase-12.4.2.300.525
4tjy3GNTankyrase-22.4.2.300.515
4l091URTankyrase-22.4.2.300.507
4avuLDRTankyrase-22.4.2.300.504
4buv16ITankyrase-22.4.2.300.500
4bjbP34Tankyrase-22.4.2.300.493
4j3lAJ5Tankyrase-22.4.2.300.487
4pnmNU1Tankyrase-22.4.2.300.485
4msk2C8Tankyrase-12.4.2.300.483
2bf7HBIPteridine reductase 11.5.1.330.459
4bufF36Tankyrase-22.4.2.300.456
3h4vDVPPteridine reductase 11.5.1.330.454
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.447
2xupTZ5Acetylcholinesterase3.1.1.70.444
2bfpH4BPteridine reductase 11.5.1.330.442
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.441
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440