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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hkiFLNTankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hkiFLNTankyrase-22.4.2.301.000
4avwG18Tankyrase-22.4.2.300.728
4buiW2ETankyrase-22.4.2.300.672
4l33F70Tankyrase-22.4.2.300.669
4bufF36Tankyrase-22.4.2.300.668
5aku29FTankyrase-22.4.2.300.665
4buuF38Tankyrase-22.4.2.300.664
4buv16ITankyrase-22.4.2.300.650
4but31FTankyrase-22.4.2.300.633
4l0s1UZTankyrase-22.4.2.300.628
4l321VFTankyrase-22.4.2.300.628
4l0i1UWTankyrase-22.4.2.300.620
4kzl20DTankyrase-22.4.2.300.606
4l2f1V3Tankyrase-22.4.2.300.601
4buxF35Tankyrase-22.4.2.300.600
3p0pNNFTankyrase-22.4.2.300.598
4l2k1V8Tankyrase-22.4.2.300.597
4hlf15ZTankyrase-22.4.2.300.594
4hlm16STankyrase-22.4.2.300.591
4l31F08Tankyrase-22.4.2.300.590
4hlh20DTankyrase-22.4.2.300.587
4kzuA73Tankyrase-22.4.2.300.586
4hl515WTankyrase-22.4.2.300.577
4j21AJ6Tankyrase-22.4.2.300.573
4bus32FTankyrase-22.4.2.300.569
4iueAJ4Tankyrase-22.4.2.300.569
4bueJQFTankyrase-22.4.2.300.568
4hknLU2Tankyrase-22.4.2.300.567
4l0v1V1Tankyrase-22.4.2.300.566
4l2g1V4Tankyrase-22.4.2.300.562
4bud29FTankyrase-22.4.2.300.558
4hmhF94Tankyrase-22.4.2.300.551
4hkkAGITankyrase-22.4.2.300.550
4buwF33Tankyrase-22.4.2.300.543
4bs4A64Tankyrase-22.4.2.300.542
4pnrG18Tankyrase-22.4.2.300.542
4j22AJ7Tankyrase-22.4.2.300.537
4krs1SXTankyrase-12.4.2.300.529
4bj9UHBTankyrase-22.4.2.300.523
4tkg09LTankyrase-22.4.2.300.509
4j3mAJ8Tankyrase-22.4.2.300.505
4j3lAJ5Tankyrase-22.4.2.300.500
4tjy3GNTankyrase-22.4.2.300.494
4pnmNU1Tankyrase-22.4.2.300.479
4l091URTankyrase-22.4.2.300.473
4i9i1DYTankyrase-12.4.2.300.472
2ejzSAHDiphthine synthase/0.460
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.459
4avuLDRTankyrase-22.4.2.300.459
4k4eK4ETankyrase-12.4.2.300.459
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
2dw4FADLysine-specific histone demethylase 1A10.453
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.450
4bjbP34Tankyrase-22.4.2.300.450
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.449
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.449
4msk2C8Tankyrase-12.4.2.300.449
4br0AU1Ectonucleoside triphosphate diphosphohydrolase 2/0.448
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.447
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.445
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3mauPLRPutative sphingosine-1-phosphate lyase/0.442
4nbb9CATerminal oxygenase component of carbazole/0.441
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440