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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hgt15GCasein kinase I isoform delta2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hgt15GCasein kinase I isoform delta2.7.11.11.000
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.496
4hgs15GCasein kinase I isoform gamma-32.7.11.10.494
2izrBRKCasein kinase I isoform gamma-32.7.11.10.486
4g170VNCasein kinase I isoform gamma-32.7.11.10.484
2izt23DCasein kinase I isoform gamma-32.7.11.10.483
4g160VMCasein kinase I isoform gamma-32.7.11.10.483
2izsBRQCasein kinase I isoform gamma-32.7.11.10.481
2c475IDCasein kinase I isoform gamma-2/0.477
1eh4IC1Casein kinase I homolog 12.7.11.10.471
3gubGUBDeath-associated protein kinase 12.7.11.10.471
4eoi1ROCyclin-dependent kinase 22.7.11.220.470
4jboWPHAurora kinase A2.7.11.10.470
3uvqFS8Mitogen-activated protein kinase 14/0.465
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.464
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.464
4fp9SAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.463
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.461
4kba1QMCasein kinase I isoform delta2.7.11.10.461
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.460
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.460
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2iw84SPCyclin-dependent kinase 22.7.11.220.458
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.458
1u54ACPActivated CDC42 kinase 1/0.457
1fvv107Cyclin-dependent kinase 22.7.11.220.456
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.456
2ckeIQUDeath-associated protein kinase 2/0.455
4fzvSAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.455
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.454
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.453
2iw94SPCyclin-dependent kinase 22.7.11.220.452
3lltANPProtein serine/threonine kinase-1/0.452
3ormAGSSerine/threonine protein kinase/0.452
3umw596Serine/threonine-protein kinase pim-12.7.11.10.452
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3kvxFMYMitogen-activated protein kinase 102.7.11.240.451
3nynSGVG protein-coupled receptor kinase 62.7.11.160.451
4eon1ROCyclin-dependent kinase 22.7.11.220.451
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.450
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.450
2b52D42Cyclin-dependent kinase 22.7.11.220.449
2izuP01Casein kinase I isoform gamma-32.7.11.10.449
3ggfGVDSerine/threonine-protein kinase 26/0.449
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.449
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.448
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.448
1k6pXN3Gag-Pol polyprotein3.4.23.160.447
3q9xEMOCasein kinase II subunit alpha2.7.11.10.447
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.447
2gs7ANPEpidermal growth factor receptor2.7.10.10.446
3qa2XNAKetohexokinase/0.446
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.446
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.446
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.445
1xjdSTUProtein kinase C theta type2.7.11.130.445
2j0lANPFocal adhesion kinase 12.7.10.20.445
3qqkX02Cyclin-dependent kinase 22.7.11.220.445
4c4h7RODual specificity protein kinase TTK2.7.12.10.445
1oi9N20Cyclin-dependent kinase 22.7.11.220.444
2p33J07Mitogen-activated protein kinase 102.7.11.240.444
3at4CCKCasein kinase II subunit alpha2.7.11.10.444
1u4dDBQActivated CDC42 kinase 1/0.443
2gr1FADFerredoxin reductase/0.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.443
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.443
1h1r6CPCyclin-dependent kinase 22.7.11.220.442
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1oiyN41Cyclin-dependent kinase 22.7.11.220.442
2j0m4STFocal adhesion kinase 12.7.10.20.442
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
4kb81QNCasein kinase I isoform delta2.7.11.10.442
3bqr4RBDeath-associated protein kinase 3/0.441
3qaiXNNKetohexokinase/0.441
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
4eym0RXMitogen-activated protein kinase 132.7.11.240.441
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.440
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.440
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.440
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440