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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hfp15UProthrombin3.4.21.5

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hfp15UProthrombin3.4.21.51.000
4ax9N5NProthrombin3.4.21.50.505
2cf9348Prothrombin3.4.21.50.499
1ypgUIRProthrombin3.4.21.50.484
2cf8ESHProthrombin3.4.21.50.483
2jh0701Prothrombin3.4.21.50.480
1ypeUIPProthrombin3.4.21.50.464
1ta6177Prothrombin3.4.21.50.462
4rn615UProthrombin3.4.21.50.460
1c4yIH3Prothrombin3.4.21.50.458
2jh6894Prothrombin3.4.21.50.454
2v3oI26Prothrombin3.4.21.50.453
2cn0F25Prothrombin3.4.21.50.451
4e7r0NWProthrombin3.4.21.50.451
2anmCDOProthrombin3.4.21.50.449
1gj5130Prothrombin3.4.21.50.448
2zfr46UProthrombin3.4.21.50.446
1oytFSNProthrombin3.4.21.50.445
2zc922UProthrombin3.4.21.50.442
5cmx0G6Prothrombin3.4.21.50.442
1o5gCR9Prothrombin3.4.21.50.441
2zi224UProthrombin3.4.21.50.441
2bvs2CEProthrombin3.4.21.50.440