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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.800
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.731
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.679
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.653
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.599
3iczPB6Farnesyl pyrophosphate synthase/0.581
3egt722Farnesyl pyrophosphate synthase/0.579
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.578
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.559
3dyh721Farnesyl pyrophosphate synthase/0.533
4nkeRISFarnesyl pyrophosphate synthase2.5.1.100.533
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.528
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.522
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.516
1rqjRISFarnesyl diphosphate synthase2.5.1.100.512
3rywK9HFarnesyl pyrophosphate synthase, putative/0.508
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.504
3oabDSTGeranyl diphosphate synthase large subunit/0.478
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.464
3krfDSTGeranyl diphosphate synthase large subunit/0.461
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.457
2eniSAHDiphthine synthase/0.452
3krfIPEGeranyl diphosphate synthase large subunit/0.452
2ekaSAHDiphthine synthase/0.450
2p6dSAHDiphthine synthase/0.450
4bfzZVZPantothenate kinase2.7.1.330.448
2egsSAHDiphthine synthase/0.446
2ehlSAHDiphthine synthase/0.445
2jlcTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.445
2dv5SAHDiphthine synthase/0.444
2p5cSAHDiphthine synthase/0.443
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.443
2dv7SAHDiphthine synthase/0.441
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.441
2emuSAHDiphthine synthase/0.440
2p5fSAHDiphthine synthase/0.440
2r5nTPPTransketolase 1/0.440
3ll9ADPIsopentenyl phosphate kinase/0.440