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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4gtm7TMProtein farnesyltransferase subunit beta2.5.1.581.000
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.650
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.636
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.621
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.603
1s63778Protein farnesyltransferase subunit beta2.5.1.580.598
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.598
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.595
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.590
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.583
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.579
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.578
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.568
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.560
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.557
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.557
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.556
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.551
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.550
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.539
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.537
4gto7TOProtein farnesyltransferase subunit beta2.5.1.580.535
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.521
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.519
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.513
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.486
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.485
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.475
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.475
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.440