scPDB - Distribution of Cavity Similarity values of 4gh3 entry / Site 1

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4gh3	0EV	Queuine tRNA-ribosyltransferase	2.4.2.29

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4gh3	0EV	Queuine tRNA-ribosyltransferase	2.4.2.29	1.000
4gh1	0WX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.645
4gkt	0O1	Queuine tRNA-ribosyltransferase	2.4.2.29	0.613
3sm0	AEK	Queuine tRNA-ribosyltransferase	2.4.2.29	0.602
3ge7	AFQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.594
4gg9	0WW	Queuine tRNA-ribosyltransferase	2.4.2.29	0.594
4fps	0UX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.571
4gi4	0EX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.564
1efz	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.550
1f3e	DPZ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.548
4hqv	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.543
1q4w	DQU	Queuine tRNA-ribosyltransferase	2.4.2.29	0.538
1ozq	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.537
2z1x	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.537
1q63	AIQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.531
4hvx	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.530
4fr1	0V2	Queuine tRNA-ribosyltransferase	2.4.2.29	0.529
1y5x	E89	Queuine tRNA-ribosyltransferase	2.4.2.29	0.522
2z1w	BDI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.522
4gcx	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.522
2bbf	344	Queuine tRNA-ribosyltransferase	2.4.2.29	0.521
1y5v	NE8	Queuine tRNA-ribosyltransferase	2.4.2.29	0.514
3gc4	AAQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.508
4hsh	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.508
4giy	0WY	Queuine tRNA-ribosyltransferase	2.4.2.29	0.493
4fsa	0V3	Queuine tRNA-ribosyltransferase	2.4.2.29	0.488
1k4g	AIQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.486
1p0e	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.479
1q66	KMB	Queuine tRNA-ribosyltransferase	2.4.2.29	0.475
2pot	GUN	Queuine tRNA-ribosyltransferase	2.4.2.29	0.475
1y5w	NEZ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.473
1pxg	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.468
2qzr	S79	Queuine tRNA-ribosyltransferase	2.4.2.29	0.468
4q8p	CKR	Queuine tRNA-ribosyltransferase	2.4.2.29	0.467
4g31	0WH	Eukaryotic translation initiation factor 2-alpha kinase 3	2.7.11.1	0.463
3lfe	Z84	Mitogen-activated protein kinase 14	/	0.459
1q65	BHB	Queuine tRNA-ribosyltransferase	2.4.2.29	0.456
4fk3	325	Serine/threonine-protein kinase B-raf	2.7.11.1	0.454
3bll	BPQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.453
1n71	COA	Aac(6')-Ii protein	/	0.452
3blo	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.451
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.448
4a4o	664	Serine/threonine-protein kinase PLK1	2.7.11.21	0.448
4z9r	NAD	Omega-3 polyunsaturated fatty acid synthase subunit PfaD	/	0.448
4g34	924	Eukaryotic translation initiation factor 2-alpha kinase 3	2.7.11.1	0.446
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.445
1dr2	TAP	Dihydrofolate reductase	1.5.1.3	0.444
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.444
1xdd	AAY	Integrin alpha-L	/	0.443
1y2e	5DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
3l8s	BFF	Mitogen-activated protein kinase 14	/	0.440
3w1w	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.440
4h7z	GUN	Queuine tRNA-ribosyltransferase	2.4.2.29	0.440