Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.649 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.632 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.628 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.619 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.611 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.596 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.572 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.569 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.563 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.519 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.517 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.511 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.505 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.504 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.499 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.499 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.498 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.495 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.494 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.494 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.492 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.492 | |
| 5dgz | L20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.490 | |
| 2xj1 | XJ1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.486 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.485 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.485 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.484 | |
| 4gu6 | 10N | Focal adhesion kinase 1 | 2.7.10.2 | 0.484 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.483 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.482 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.481 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.481 | |
| 3c4e | C4E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.480 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.480 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.479 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.479 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.479 | |
| 1oir | HDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 2csn | CKI | Casein kinase I homolog 1 | 2.7.11.1 | 0.478 | |
| 2pe0 | 39Z | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.478 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.477 | |
| 3hzt | J60 | Calmodulin-like domain protein kinase isoform 3 | / | 0.477 | |
| 4lmu | QUE | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.477 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.477 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.476 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.476 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.475 | |
| 3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.474 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.474 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.473 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.473 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.473 | |
| 2uzo | C62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.472 | |
| 4dtk | 7LI | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 4gfo | 0X2 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.472 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.470 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2c5n | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2jed | LG8 | Protein kinase C theta type | 2.7.11.13 | 0.470 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.470 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 4erw | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 3dcv | 55E | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4qml | ANP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.468 | |
| 4feq | 0T8 | Tyrosine-protein kinase receptor TYRO3 | 2.7.10.1 | 0.467 | |
| 4fkg | 4CK | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.467 | |
| 2xiy | XIY | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.466 | |
| 3iw4 | LW4 | Protein kinase C alpha type | 2.7.11.13 | 0.466 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.466 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 2jkq | VG8 | Focal adhesion kinase 1 | 2.7.10.2 | 0.465 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.465 | |
| 3nlb | 5BE | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 4lm5 | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.464 | |
| 3v5j | 0F2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.464 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.464 | |
| 4aoj | V4Z | High affinity nerve growth factor receptor | 2.7.10.1 | 0.464 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.462 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.462 | |
| 3jxw | LXG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.462 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.462 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.462 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.461 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.461 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 3bgp | VX1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 3bgz | VX3 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.461 | |
| 3i81 | EBI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.461 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.461 | |
| 3p5k | P5K | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 4fkv | 61K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.460 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.459 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.459 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 3mtl | FEF | Cyclin-dependent kinase 16 | 2.7.11.22 | 0.459 | |
| 4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.459 | |
| 4foc | 0UU | ALK tyrosine kinase receptor | 2.7.10.1 | 0.459 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.459 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.459 | |
| 1pkg | ADP | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.458 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.458 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.458 | |
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.458 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.457 | |
| 2ydk | YDK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.457 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.457 | |
| 1csn | ATP | Casein kinase I homolog 1 | 2.7.11.1 | 0.456 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 1xws | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 1y91 | CT9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.456 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.456 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.455 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.455 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.455 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.455 | |
| 4ct2 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.455 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.454 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.454 | |
| 3bhy | 7CP | Death-associated protein kinase 3 | / | 0.454 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.454 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.454 | |
| 5c8a | 5AD | Probable transcriptional regulator | / | 0.454 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2c5y | MTW | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.453 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.453 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.453 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.452 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.452 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.452 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 4enx | Z20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.452 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.451 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.451 | |
| 2fum | MIX | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.451 | |
| 3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.451 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4krc | AGS | Cyclin-dependent protein kinase PHO85 | 2.7.11.22 | 0.451 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3qqk | X02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4brx | KGW | Focal adhesion kinase 1 | 2.7.10.2 | 0.450 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.450 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.449 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1ir3 | ANP | Insulin receptor | 2.7.10.1 | 0.449 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.449 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.449 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.449 | |
| 2biy | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.448 | |
| 3cy3 | JN5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3eyh | IZA | Tyrosine-protein kinase JAK1 | / | 0.448 | |
| 3jpv | 1DR | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.448 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.448 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.448 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.448 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.448 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.447 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3et7 | 349 | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.447 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.447 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.447 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.447 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.447 | |
| 4gii | 0X6 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.447 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.447 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.447 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.447 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.447 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.447 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 3i8a | N22 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.446 | |
| 4ewh | T77 | Activated CDC42 kinase 1 | / | 0.446 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.446 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.445 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2jko | BIJ | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 2uzb | C75 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.445 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.445 | |
| 4fkt | 48K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 4o4f | ATP | Kinase | / | 0.445 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 1h1q | 2A6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2bil | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 2bkz | SBC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.444 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.444 | |
| 3vbq | 0F5 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.444 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.444 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 2fzk | CTP | Aspartate carbamoyltransferase regulatory chain | / | 0.443 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 5auv | AGI | Death-associated protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1vyw | 292 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.442 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.442 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.442 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.442 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.442 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.442 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1syn | F89 | Thymidylate synthase | / | 0.441 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.441 | |
| 3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3nsz | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4ach | KDI | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4dta | ADN | APH(2'')-Id | / | 0.441 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.441 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.441 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.441 | |
| 4k8a | K8A | Focal adhesion kinase 1 | 2.7.10.2 | 0.441 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 4z9r | NAD | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.441 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.441 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.440 | |
| 2c6o | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4jbo | WPH | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 |