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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g67SAHUncharacterized ACR, COG1565 superfamily

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g67SAHUncharacterized ACR, COG1565 superfamily/1.000
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.476
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.468
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.466
1ppjANYCytochrome b/0.465
1bwlFMNNADPH dehydrogenase 11.6.99.10.464
5a27MYAGlycylpeptide N-tetradecanoyltransferase/0.463
1uydPU8Heat shock protein HSP 90-alpha/0.461
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.459
1fm4DXCMajor pollen allergen Bet v 1-L/0.458
3jv7NADSecondary alcohol dehydrogenase/0.457
4a87NARMajor pollen allergen Bet v 1-A/0.456
4b10NHWGlycylpeptide N-tetradecanoyltransferase/0.456
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.456
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.454
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.454
1xe55FEPlasmepsin-23.4.23.390.453
3fpjSAMUncharacterized protein/0.453
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.451
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.450
1bwsNDPGDP-L-fucose synthase/0.448
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
3vt7VDXVitamin D3 receptor/0.447
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.446
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.446
3nxxNDPDihydrofolate reductase1.5.1.30.446
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.446
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.446
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.446
1xe65FPPlasmepsin-23.4.23.390.445
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.445
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.444
2w9hTOPDihydrofolate reductase1.5.1.30.444
3kpkFADSulfide-quinone reductase/0.444
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.444
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.443
5hs1VORLanosterol 14-alpha demethylase/0.443
1ndiCOACarnitine O-acetyltransferase2.3.1.70.442
2znnS44Peroxisome proliferator-activated receptor alpha/0.442
3w5rLOAVitamin D3 receptor/0.442
5ag6MYAGlycylpeptide N-tetradecanoyltransferase/0.442
1diuBDMDihydrofolate reductase1.5.1.30.441
1fmlRTLRetinol dehydratase/0.441
1mp0NADAlcohol dehydrogenase class-31.1.1.10.441
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.441
1rkhVD2Vitamin D3 receptor/0.441
1s0xC3SNuclear receptor ROR-alpha/0.441
1s19MC9Vitamin D3 receptor/0.441
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.441
3copADPGlycogen synthase2.4.1.210.441
1joaFADNADH peroxidase1.11.1.10.440
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.440
3mnrSD1Heat shock protein HSP 90-alpha/0.440
3vt3VDXVitamin D3 receptor/0.440
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.440
4lrzADPPEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.440
4tmcFMNOld yellow enzyme/0.440
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.440