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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.797
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.731
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.669
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.644
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.638
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.628
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.609
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.609
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.590
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.590
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.588
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.582
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.575
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.571
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.565
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.563
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.557
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.481
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440