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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fz60VGTyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fz60VGTyrosine-protein kinase SYK2.7.10.21.000
4fyn0VETyrosine-protein kinase SYK2.7.10.20.705
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.610
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.600
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.579
2j0m4STFocal adhesion kinase 12.7.10.20.544
3vf9477Tyrosine-protein kinase SYK2.7.10.20.544
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.540
3emg685Tyrosine-protein kinase SYK2.7.10.20.537
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.526
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.517
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.514
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.512
2of2547Tyrosine-protein kinase Lck2.7.10.20.506
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.504
2xyuQ9GEphrin type-A receptor 42.7.10.10.502
4tuvCPZCytochrome P450 1191.140.498
2itnANPEpidermal growth factor receptor2.7.10.10.496
3vf80JETyrosine-protein kinase SYK2.7.10.20.495
2of4979Tyrosine-protein kinase Lck2.7.10.20.494
2x9fX9FEphrin type-B receptor 42.7.10.10.493
1m17AQ4Epidermal growth factor receptor2.7.10.10.492
3lq5SLQCyclin-dependent kinase 92.7.11.220.492
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.491
2ittAEEEpidermal growth factor receptor2.7.10.10.491
4bchT7ZCyclin-dependent kinase 92.7.11.220.490
4wboANWRhodopsin kinase/0.490
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.489
4jq7KJQEpidermal growth factor receptor2.7.10.10.489
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.489
2j0k4STFocal adhesion kinase 12.7.10.20.486
2xp2VGHALK tyrosine kinase receptor2.7.10.10.486
2vn0TDZCytochrome P450 2C8/0.485
2vzmNRBCytochrome P450 monooxygenase PikC/0.485
4bcqTJFCyclin-dependent kinase 22.7.11.220.484
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.484
4fob0USALK tyrosine kinase receptor2.7.10.10.484
4jq8KJ8Epidermal growth factor receptor2.7.10.10.484
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.482
2j0j4STFocal adhesion kinase 12.7.10.20.482
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.481
2zbzVDXVitamin D3 dihydroxylase/0.481
4gk2L66Ephrin type-A receptor 32.7.10.10.481
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.480
2q0bACPFibroblast growth factor receptor 2/0.479
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.479
4wkqIREEpidermal growth factor receptor2.7.10.10.479
1iwiCAMCamphor 5-monooxygenase1.14.15.10.478
1yrcCAMCamphor 5-monooxygenase1.14.15.10.478
4jia1K3Tyrosine-protein kinase JAK2/0.478
5e8xSTUTGF-beta receptor type-12.7.11.300.478
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2c7xNRBCytochrome P450 monooxygenase PikC/0.476
2qo9ANPEphrin type-A receptor 32.7.10.10.476
2y6o1N1Ephrin type-A receptor 42.7.10.10.476
3ielU5PRibonuclease TTHA02523.10.476
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.476
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.476
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.476
6cp4CAMCamphor 5-monooxygenase1.14.15.10.476
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.475
1u54ACPActivated CDC42 kinase 1/0.474
4ubsDIFPentalenic acid synthase1.14.15.110.474
1wvxBD4Death-associated protein kinase 12.7.11.10.473
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.473
4gk3L87Ephrin type-A receptor 32.7.10.10.473
2w4iVGAGlutamate racemase/0.472
2xru400Aurora kinase A2.7.11.10.472
3fwjCAMCamphor 5-monooxygenase1.14.15.10.472
3vjoANPEpidermal growth factor receptor2.7.10.10.472
3zewSTUEphrin type-B receptor 42.7.10.10.472
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.472
2ijmADPFocal adhesion kinase 12.7.10.20.471
2po7CHDFerrochelatase, mitochondrial4.99.1.10.471
2yn8STUEphrin type-B receptor 42.7.10.10.471
3vjnANPEpidermal growth factor receptor2.7.10.10.471
4anqVGHALK tyrosine kinase receptor2.7.10.10.471
4nks2M2Fibroblast growth factor receptor 1/0.471
2hk51BMTyrosine-protein kinase HCK2.7.10.20.470
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.470
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.470
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.470
3w2o03PEpidermal growth factor receptor2.7.10.10.470
4l4cCAMCamphor 5-monooxygenase1.14.15.10.470
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1nooCAHCamphor 5-monooxygenase1.14.15.10.469
1pkdUCNCyclin-dependent kinase 22.7.11.220.469
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.469
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.469
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.469
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.468
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3pxkPXKFocal adhesion kinase 12.7.10.20.468
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.468
1kkq471Peroxisome proliferator-activated receptor alpha/0.467
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.467
1xjdSTUProtein kinase C theta type2.7.11.130.467
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.467
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.467
4b7dQLECytochrome P450 monooxygenase PikC/0.467
4jboWPHAurora kinase A2.7.11.10.467
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2vwy7X5Ephrin type-B receptor 42.7.10.10.466
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3kf7L9GMitogen-activated protein kinase 14/0.466
3koo24DBifunctional epoxide hydrolase 23.3.2.100.466
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.466
1m13HYFNuclear receptor subfamily 1 group I member 2/0.465
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.465
2om9AJAPeroxisome proliferator-activated receptor gamma/0.465
2pwlACPFibroblast growth factor receptor 2/0.465
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.465
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.465
3fwfCAMCamphor 5-monooxygenase1.14.15.10.465
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.465
3nx4NAPPutative oxidoreductase/0.465
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4bb432WEphrin type-B receptor 42.7.10.10.465
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.465
4g6oE28Mitogen-activated protein kinase 12.7.11.240.465
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.465
1t86CAMCamphor 5-monooxygenase1.14.15.10.464
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2vww7X2Ephrin type-B receptor 42.7.10.10.464
3amyAGICasein kinase II subunit alpha2.7.11.10.464
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.464
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.463
2m56CAMCamphor 5-monooxygenase1.14.15.10.463
2vx07X7Ephrin type-B receptor 42.7.10.10.463
4b7sQLECytochrome P450 monooxygenase PikC/0.463
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
1dz6CAMCamphor 5-monooxygenase1.14.15.10.462
1dz8CAMCamphor 5-monooxygenase1.14.15.10.462
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.462
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2feuCAMCamphor 5-monooxygenase1.14.15.10.462
2ituITQEpidermal growth factor receptor2.7.10.10.462
2qblCAMCamphor 5-monooxygenase1.14.15.10.462
2vwu7X1Ephrin type-B receptor 42.7.10.10.462
3vt8YI3Vitamin D3 receptor/0.462
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.462
3zuxTCHTransporter/0.462
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.462
4c4jX21Dual specificity protein kinase TTK2.7.12.10.462
1phgMYTCamphor 5-monooxygenase1.14.15.10.461
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.461
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.461
2vx17X8Ephrin type-B receptor 42.7.10.10.461
3icsADPCoenzyme A disulfide reductase/0.461
4bcoT6QCyclin-dependent kinase 22.7.11.220.461
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.461
4g2fC07Ephrin type-A receptor 32.7.10.10.461
4ienCOAPutative acyl-CoA hydrolase/0.461
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.461
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.461
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.461
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1dz4CAMCamphor 5-monooxygenase1.14.15.10.460
1ie4T44Transthyretin/0.460
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.460
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.460
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.460
4fa60TAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.460
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.460
1uyrD1LAcetyl-CoA carboxylase/0.459
1zhwHC2Oxysterol-binding protein homolog 4/0.459
2pzrACPFibroblast growth factor receptor 2/0.459
2znq401Peroxisome proliferator-activated receptor delta/0.459
3vewADPnebramycin 5' synthase6.1.2.20.459
4jkt04AGlutaminase kidney isoform, mitochondrial3.5.1.20.459
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.458
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.458
3ac2KSETyrosine-protein kinase Lck2.7.10.20.458
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.458
3zk5Z18Cytochrome P450 monooxygenase PikC/0.458
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4bcmT7ZCyclin-dependent kinase 22.7.11.220.458
4fz70VHTyrosine-protein kinase SYK2.7.10.20.458
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.458
4ylfFADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog/0.458
5e8wSTUTGF-beta receptor type-12.7.11.300.458
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1ml6GBXGlutathione S-transferase A22.5.1.180.457
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.457
3ac1KZITyrosine-protein kinase Lck2.7.10.20.457
3dhoB2MStreptogramin A acetyltransferase2.3.10.457
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.457
4g170VNCasein kinase I isoform gamma-32.7.11.10.457
4hnc0UTMandelate racemase/0.457
5aaaVGHALK tyrosine kinase receptor2.7.10.10.457
1iwjCAMCamphor 5-monooxygenase1.14.15.10.456
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.456
1t85CAMCamphor 5-monooxygenase1.14.15.10.456
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.456
2itwITQEpidermal growth factor receptor2.7.10.10.456
3gwfFADCyclohexanone monooxygenase/0.456
3lfnA27Cyclin-dependent kinase 22.7.11.220.456
3sx2NADUncharacterized protein/0.456
3tucFPWTyrosine-protein kinase SYK2.7.10.20.456
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
4i231C9Epidermal growth factor receptor2.7.10.10.456
4jr3KJREpidermal growth factor receptor2.7.10.10.456
5dr6SKEAurora kinase A2.7.11.10.456
5eypLOCTubulin beta chain/0.456
1eh4IC1Casein kinase I homolog 12.7.11.10.455
1jipKTN6-deoxyerythronolide B hydroxylase/0.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.455
1yrdCAMCamphor 5-monooxygenase1.14.15.10.455
2btsU32Cyclin-dependent kinase 22.7.11.220.455
2c6hPXICytochrome P450 monooxygenase PikC/0.455
2pzpACPFibroblast growth factor receptor 2/0.455
2qbnCAMCamphor 5-monooxygenase1.14.15.10.455
2y4gTIRTamL/0.455
2zuiCAMCamphor 5-monooxygenase1.14.15.10.455
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.455
3ictFADCoenzyme A disulfide reductase/0.455
3ictADPCoenzyme A disulfide reductase/0.455
3oom507Activin receptor type-12.7.11.300.455
3pm0BHFCytochrome P450 1B1/0.455
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.455
3zuyTCHTransporter/0.455
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4j6dTESCytochrome P450 monooxygenase/0.455
4jrvKJVEpidermal growth factor receptor2.7.10.10.455
5ce3ADPProtein kinase YopO/0.455
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.454
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.454
1t88CAMCamphor 5-monooxygenase1.14.15.10.454
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.454
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
2zaxCAMCamphor 5-monooxygenase1.14.15.10.454
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.454
3sheI85MAP kinase-activated protein kinase 32.7.11.10.454
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
3uvqFS8Mitogen-activated protein kinase 14/0.454
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.454
4xumIMNPeroxisome proliferator-activated receptor gamma/0.454
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.453
2v7a627Tyrosine-protein kinase ABL12.7.10.20.453
2vwz7X6Ephrin type-B receptor 42.7.10.10.453
3kpkFADSulfide-quinone reductase/0.453
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.453
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.453
4cp4CAMCamphor 5-monooxygenase1.14.15.10.453
4g3rCAMCamphor 5-monooxygenase1.14.15.10.453
4jlk1NODeoxycytidine kinase2.7.1.740.453
4xldBRLPeroxisome proliferator-activated receptor gamma/0.453
5aabVGHALK tyrosine kinase receptor2.7.10.10.453
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.452
2cppCAMCamphor 5-monooxygenase1.14.15.10.452
3fwiCAMCamphor 5-monooxygenase1.14.15.10.452
3hl7I47Mitogen-activated protein kinase 14/0.452
4b99R4LMitogen-activated protein kinase 72.7.11.240.452
4ccuAWFALK tyrosine kinase receptor2.7.10.10.452
4enhFVXCholesterol 24-hydroxylase/0.452
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.452
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.452
4l4dCAMCamphor 5-monooxygenase1.14.15.10.452
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.452
4ylhYE1(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase/0.452
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1oz1FPHMitogen-activated protein kinase 14/0.451
1zhzERGOxysterol-binding protein homolog 4/0.451
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.451
2gjlFMNNitronate monooxygenase1.13.12.160.451
2itzIREEpidermal growth factor receptor2.7.10.10.451
3e5aVX6Aurora kinase A2.7.11.10.451
3ibeL64Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3zcw4A2Kinesin-like protein KIF11/0.451
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.451
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.451
1me8RVPInosine-5'-monophosphate dehydrogenase/0.450
1mqbANPEphrin type-A receptor 22.7.10.10.450
1xddAAYIntegrin alpha-L/0.450
2a1nCAMCamphor 5-monooxygenase1.14.15.10.450
2y00Y01Beta-1 adrenergic receptor/0.450
2zawCAMCamphor 5-monooxygenase1.14.15.10.450
3wrmCAMCamphor 5-monooxygenase1.14.15.10.450
4ccbOFGALK tyrosine kinase receptor2.7.10.10.450
4ek1CAMCamphor 5-monooxygenase1.14.15.10.450
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.450
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.450
4g47TZFMycocyclosin synthase1.14.21.90.450
4l49CAMCamphor 5-monooxygenase1.14.15.10.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
5cp4CAMCamphor 5-monooxygenase1.14.15.10.450
1g4tFTPThiamine-phosphate synthase/0.449
1uyuCAMCamphor 5-monooxygenase1.14.15.10.449
2h96893Mitogen-activated protein kinase 82.7.11.240.449
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.449
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.449
2y3rTRKTamL/0.449
2zdt46CMitogen-activated protein kinase 102.7.11.240.449
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.449
2zybKSLTyrosine-protein kinase Lck2.7.10.20.449
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.449
3vrwYS5Vitamin D3 receptor/0.449
3zxtACPDeath-associated protein kinase 12.7.11.10.449
4g48PZBMycocyclosin synthase1.14.21.90.449
4h9506UDihydrofolate reductase1.5.1.30.449
4kkyCAMCamphor 5-monooxygenase1.14.15.10.449
4l4aCAMCamphor 5-monooxygenase1.14.15.10.449
4l4fCAMCamphor 5-monooxygenase1.14.15.10.449
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.448
1t87CAMCamphor 5-monooxygenase1.14.15.10.448
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.448
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.448
2itpAEEEpidermal growth factor receptor2.7.10.10.448
2oji33AMitogen-activated protein kinase 12.7.11.240.448
2znnS44Peroxisome proliferator-activated receptor alpha/0.448
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.448
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.448
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.448
3vvpBNUUncharacterized protein/0.448
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.448
4klrCHDFerrochelatase, mitochondrial4.99.1.10.448
4l4bCAMCamphor 5-monooxygenase1.14.15.10.448
5hs1VORLanosterol 14-alpha demethylase/0.448
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.447
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.447
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.447
2q59240Peroxisome proliferator-activated receptor gamma/0.447
3bfb9ODPheromone-binding protein ASP1/0.447
3c4zADPRhodopsin kinase/0.447
3c50ADPRhodopsin kinase/0.447
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3k4nFADPyranose 2-oxidase/0.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
3vtdTKDVitamin D3 receptor/0.447
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.447
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
4gu94GUFocal adhesion kinase 12.7.10.20.447
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.447
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.447
4o71CPBBromodomain-containing protein 4/0.447
4oaeCLMUncharacterized protein/0.447
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.447
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.447
1bsvNDPGDP-L-fucose synthase/0.446
1bygSTUTyrosine-protein kinase CSK/0.446
1nhhANPDNA mismatch repair protein MutL/0.446
1rv1IMZE3 ubiquitin-protein ligase Mdm26.3.20.446
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.446
2hasC3OVitamin D3 receptor/0.446
2qocANPEphrin type-A receptor 32.7.10.10.446
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.446
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.446
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.446
3vt7VDXVitamin D3 receptor/0.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.446
4h9814QUncharacterized protein/0.446
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.446
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.446
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.446
1phePIYCamphor 5-monooxygenase1.14.15.10.445
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.445
2r43G3GGag-Pol polyprotein3.4.23.160.445
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.445
3uowXMPGMP synthase [glutamine-hydrolyzing]/0.445
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.445
4crsAGSSerine/threonine-protein kinase N22.7.11.130.445
4hvi19STyrosine-protein kinase JAK32.7.10.20.445
4i3wNADAldehyde dehydrogenase (NAD+)/0.445
4i4e1BQFocal adhesion kinase 12.7.10.20.445
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.445
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.445
4j97ACPFibroblast growth factor receptor 2/0.445
4l4eCAMCamphor 5-monooxygenase1.14.15.10.445
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.445
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.445
4xiwAZMCarbonic anhydrase, alpha type/0.445
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.444
2bujSTUSerine/threonine-protein kinase 16/0.444
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.444
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.444
2qe6SAMUncharacterized protein/0.444
2wleCOAPolysialic acid O-acetyltransferase/0.444
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.444
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3inxJZCHeat shock protein HSP 90-alpha/0.444
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.444
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.444
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.444
3qlwN22Dihydrofolate reductase1.5.1.30.444
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
4q5hANPProtein kinase OspG2.70.444
4yuqKS1Calmodulin-like domain protein kinase/0.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.443
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
2wouZZFTGF-beta receptor type-12.7.11.300.443
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
3h0sB38Acetyl-CoA carboxylase/0.443
3p7nFMNLight-activated DNA-binding protein EL222/0.443
3pgqGY3Acetyl-CoA carboxylase/0.443
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.443
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
3ttjJBIMitogen-activated protein kinase 102.7.11.240.443
3vt9YI4Vitamin D3 receptor/0.443
3wrlCAMCamphor 5-monooxygenase1.14.15.10.443
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4b4oNDPEpimerase family protein SDR39U1/0.443
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.443
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.443
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.443
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.443
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.443
4xpdACON-terminal acetyltransferase A complex subunit NAT52.3.10.443
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.443
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2qboCAMCamphor 5-monooxygenase1.14.15.10.442
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.442
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.442
3mdvCL6Cholesterol 24-hydroxylase/0.442
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.442
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.442
4az3S35Lysosomal protective protein3.4.16.50.442
4f630S7Fibroblast growth factor receptor 1/0.442
4g1wG1WMitogen-activated protein kinase 82.7.11.240.442
4iebANPCalmodulin-domain protein kinase 1/0.442
4nc3ERM5-hydroxytryptamine receptor 2B/0.442
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.442
5eoxADPType 4 fimbrial biogenesis protein PilM/0.442
1fmlRTLRetinol dehydratase/0.441
1ie9VDXVitamin D3 receptor/0.441
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
1ysx4EBSerum albumin/0.441
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2g20L1ARenin3.4.23.150.441
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
2jkoBIJFocal adhesion kinase 12.7.10.20.441
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.441
2ze2T27Gag-Pol polyprotein2.7.7.490.441
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.441
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.441
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3uyt0CKCasein kinase I isoform delta2.7.11.10.441
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4ie0PD2Alpha-ketoglutarate-dependent dioxygenase FTO/0.441
4kbk1QGCasein kinase I isoform delta2.7.11.10.441
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.441
4o4fATPKinase/0.441
4qknJMSAlpha-ketoglutarate-dependent dioxygenase FTO/0.441
4utdACPAurora kinase A2.7.11.10.441
1eupASD6-deoxyerythronolide B hydroxylase/0.440
1og5SWFCytochrome P450 2C9/0.440
1uy8PU5Heat shock protein HSP 90-alpha/0.440
2ca0PXICytochrome P450 monooxygenase PikC/0.440
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.440
2rh9IGPTryptophan synthase alpha chain/0.440
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.440
2z97CAMCamphor 5-monooxygenase1.14.15.10.440
3bfa9ODOdorant binding protein ASP1/0.440
3cgoJNOMitogen-activated protein kinase 102.7.11.240.440
3dxjNE6DNA-directed RNA polymerase subunit beta/0.440
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.440
3lxiCAMCytochrome P450/0.440
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.440
4a81DXCMajor pollen allergen Bet v 1-A/0.440
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.440
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.440
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.440
4foc0UUALK tyrosine kinase receptor2.7.10.10.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.440
4j6bPLOCytochrome P450 monooxygenase/0.440
4kb81QNCasein kinase I isoform delta2.7.11.10.440
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.440
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440