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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fwjFADLysine-specific histone demethylase 1B1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fwjFADLysine-specific histone demethylase 1B11.000
2uxxFAJLysine-specific histone demethylase 1A10.545
2iw5FADLysine-specific histone demethylase 1A10.542
5l3dFADLysine-specific histone demethylase 1A10.528
3cn8FADPolyamine oxidase FMS1/0.515
4echFADPolyamine oxidase FMS1/0.504
3cntFADPolyamine oxidase FMS1/0.490
3cndFADPolyamine oxidase FMS1/0.480
1xpqFADPolyamine oxidase FMS1/0.478
3zdnFADMonoamine oxidase N1.4.3.40.468
3vqrFADPutative oxidoreductase/0.466
2babFADPutative aminooxidase/0.463
2yg7FADPutrescine oxidase/0.461
3k7tFAD6-hydroxy-L-nicotine oxidase/0.458
3rhaFDAPutrescine oxidase/0.456
4i58FADCyclohexylamine Oxidase/0.456
2ba9FADPutative aminooxidase/0.452
2bacFADPutative aminooxidase/0.449
2b9xFADPutative aminooxidase/0.448
3kpfFADPolyamine oxidase1.5.3.140.448