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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv9E71Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fv9E71Mitogen-activated protein kinase 12.7.11.241.000
4fv6E57Mitogen-activated protein kinase 12.7.11.240.525
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.512
3i60E86Mitogen-activated protein kinase 12.7.11.240.487
4gt3ATPMitogen-activated protein kinase 12.7.11.240.474
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.469
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.468
1tvoFRZMitogen-activated protein kinase 12.7.11.240.467
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.467
2ojj82AMitogen-activated protein kinase 12.7.11.240.465
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.464
4h3qANPMitogen-activated protein kinase 12.7.11.240.463
2fvdLIACyclin-dependent kinase 22.7.11.220.462
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.462
2vu3LZECyclin-dependent kinase 22.7.11.220.460
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.455
4bcmT7ZCyclin-dependent kinase 22.7.11.220.454
4fuxE75Mitogen-activated protein kinase 12.7.11.240.454
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.446
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.445
3my5RFZCyclin-dependent kinase 22.7.11.220.443
1qmzATPCyclin-dependent kinase 22.7.11.220.442
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.441
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
3rak03ZCyclin-dependent kinase 22.7.11.220.440
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.440