Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 1.000 | |
| 4fv4 | EK7 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.553 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.535 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.529 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.524 | |
| 4g6o | E28 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.522 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.519 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.518 | |
| 2pe0 | 39Z | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.514 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.514 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.513 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.513 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.512 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.512 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.511 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.510 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.510 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.510 | |
| 2c4g | 514 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.509 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.508 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.507 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.506 | |
| 2wtd | ZZK | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.505 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.505 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.505 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.505 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.504 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.503 | |
| 2wti | WTI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.502 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.501 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.501 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.501 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.500 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.500 | |
| 4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.500 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.499 | |
| 4h3p | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.499 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.498 | |
| 2qhn | 582 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.498 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.498 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.497 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.497 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.496 | |
| 3pxk | PXK | Focal adhesion kinase 1 | 2.7.10.2 | 0.496 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.495 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.495 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.495 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.494 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.494 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.494 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.494 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.493 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.493 | |
| 4fv2 | EK5 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.493 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.493 | |
| 4fsy | HK7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.492 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.491 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.491 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.490 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.489 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.489 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.488 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.488 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.487 | |
| 2vtp | LZ9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.486 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.486 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.485 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.485 | |
| 2oji | 33A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.484 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.484 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 4fki | 09K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.483 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.483 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.483 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.482 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.481 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 2wmv | ZYV | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 4bdf | H3R | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.480 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.480 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.480 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.479 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.479 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.479 | |
| 3umw | 596 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.479 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.479 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.479 | |
| 2bkz | SBC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 2r3g | SC9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.478 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.478 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.478 | |
| 4fta | H5K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.477 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.477 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.477 | |
| 4fkj | 11K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.477 | |
| 2biy | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.476 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 2x8e | X8E | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.476 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.476 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 4gh2 | HK0 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.476 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.476 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.475 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 3qqk | X02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 4fux | E75 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.475 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.474 | |
| 3qrt | X14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.474 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.474 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.474 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.473 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.473 | |
| 4a9u | A9U | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.473 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.472 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.472 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.472 | |
| 2wmx | ZY6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 3qcy | 3Q3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.472 | |
| 4a9t | A9T | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.472 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.472 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 2w7x | D1A | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.471 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.471 | |
| 3rm7 | 19Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 3w55 | 1FM | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.471 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.470 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 3qyw | 6PB | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.470 | |
| 3tei | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.470 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.470 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.469 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.468 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.468 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.467 | |
| 2btr | U73 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 2r3f | SC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 2vtn | LZ7 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 2yir | YIR | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.467 | |
| 2b9f | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.466 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 2wtj | WTJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.466 | |
| 3qx2 | X63 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.465 | |
| 3qzh | X69 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.465 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.465 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.464 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.464 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.464 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.464 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.464 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.464 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.463 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2xb7 | GUI | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.463 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 4ccu | AWF | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.463 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2c47 | 5ID | Casein kinase I isoform gamma-2 | / | 0.462 | |
| 3r1s | X73 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.462 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.462 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.462 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.461 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 2j0j | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.460 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.460 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 4bda | VFB | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.460 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.460 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.459 | |
| 3qru | X19 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 4aw0 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.458 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3otu | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.458 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 1uv5 | BRW | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.457 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3orz | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.457 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.457 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.457 | |
| 2b52 | D42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 3nup | 3NU | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.456 | |
| 3nuy | JPZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3qxo | X65 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3r8l | Z30 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3s2p | PMU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.456 | |
| 4ct2 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4bdg | P3J | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.455 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.455 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.454 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.454 | |
| 1vyz | N5B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.454 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
| 3ogq | AB1 | Pol polyprotein | / | 0.454 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3roy | 22Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.454 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.453 | |
| 3ig7 | EFP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3qtr | X36 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3rk7 | 08Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.453 | |
| 1fvt | 106 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1pxm | CK5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.452 | |
| 4b7t | CWT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 4ftj | H8K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.451 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.451 | |
| 2c6i | DT1 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.451 | |
| 4mf1 | 29Y | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.451 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.450 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.450 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3r6x | X84 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.450 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.450 | |
| 1gih | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1ke5 | LS1 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1urw | I1P | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.449 | |
| 2vtj | LZ4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 4ek6 | 10K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4gj2 | 0XH | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.449 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.448 | |
| 1w0x | OLO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.448 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.448 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3bkb | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.448 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.448 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.448 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.448 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.448 | |
| 5ani | ES4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1tqm | ANP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.447 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.447 | |
| 2ojj | 82A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3r7e | X88 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3rkb | 12Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4acd | GR9 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.447 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 3rjc | 06Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3rvg | 17P | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.446 | |
| 3v8t | 477 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.446 | |
| 4fkp | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4fkt | 48K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.446 | |
| 1c70 | L75 | Protease | / | 0.445 | |
| 3du8 | 553 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 3lct | ADP | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 3qtw | X3A | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4fyn | 0VE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.445 | |
| 1v1k | 3FP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2qi3 | MZ5 | Gag-Pol polyprotein | / | 0.444 | |
| 2r64 | 740 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2vtl | LZ5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.444 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2ycr | HCW | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3qql | X03 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3r7v | Z02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 5cu6 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1eby | BEB | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.443 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2a0c | CK9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3qtu | X44 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3r8p | Z46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3v5j | 0F2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.443 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4bl1 | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.443 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4fks | 46K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.442 | |
| 1oir | HDY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.442 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 3ka0 | MK3 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3tiz | 3TI | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4jay | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.442 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4k8a | K8A | Focal adhesion kinase 1 | 2.7.10.2 | 0.442 | |
| 1tqp | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.441 | |
| 1z5m | LI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.441 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 3igg | EFQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.441 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.441 | |
| 3r1y | X76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4yuq | KS1 | Calmodulin-like domain protein kinase | / | 0.441 | |
| 1c6z | ROC | Protease | / | 0.440 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1h0w | 207 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1oit | HDT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1pye | PM1 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2vtq | LZA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2yer | TQ1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 3c4x | ATP | Rhodopsin kinase | / | 0.440 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.440 | |
| 4eol | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.440 |