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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv2EK5Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fv2EK5Mitogen-activated protein kinase 12.7.11.241.000
4fv9E71Mitogen-activated protein kinase 12.7.11.240.537
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.532
2ojj82AMitogen-activated protein kinase 12.7.11.240.521
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.509
4fv6E57Mitogen-activated protein kinase 12.7.11.240.506
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.505
4b99R4LMitogen-activated protein kinase 72.7.11.240.497
3bqr4RBDeath-associated protein kinase 3/0.491
4l9i8PRRhodopsin kinase/0.490
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.485
3i60E86Mitogen-activated protein kinase 12.7.11.240.476
3c4xATPRhodopsin kinase/0.475
4gt3ATPMitogen-activated protein kinase 12.7.11.240.473
4qnyANPMitogen activated protein kinase, putative/0.468
2uzbC75Cyclin-dependent kinase 22.7.11.220.466
4h3qANPMitogen-activated protein kinase 12.7.11.240.466
4fuxE75Mitogen-activated protein kinase 12.7.11.240.465
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.464
4bcmT7ZCyclin-dependent kinase 22.7.11.220.462
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.461
4aguD15Cyclin-dependent kinase-like 1/0.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.459
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.458
4s33ANPMitogen-activated protein kinase 12.7.11.240.457
2yaaATPDeath-associated protein kinase 2/0.456
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.456
3my5RFZCyclin-dependent kinase 22.7.11.220.455
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.454
1tvoFRZMitogen-activated protein kinase 12.7.11.240.451
2pvmP29Casein kinase II subunit alpha2.7.11.10.451
3c4wATPRhodopsin kinase/0.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.448
4eooATPCyclin-dependent kinase 22.7.11.220.448
3nynSGVG protein-coupled receptor kinase 62.7.11.160.447
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.447
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.447
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.445
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.445
2j0lANPFocal adhesion kinase 12.7.10.20.444
3sa0NRAMitogen-activated protein kinase 12.7.11.240.443
4hge15VTyrosine-protein kinase JAK2/0.443
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.442
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2xvdAS6Ephrin type-B receptor 42.7.10.10.441
5av2KMPDeath-associated protein kinase 12.7.11.10.440