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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv0EK3Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fv0EK3Mitogen-activated protein kinase 12.7.11.241.000
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.528
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.478
4b99R4LMitogen-activated protein kinase 72.7.11.240.472
4i22IREEpidermal growth factor receptor2.7.10.10.455
4fuxE75Mitogen-activated protein kinase 12.7.11.240.454
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.453
4gt3ATPMitogen-activated protein kinase 12.7.11.240.453
3sa0NRAMitogen-activated protein kinase 12.7.11.240.452
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.449
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447