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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fue7UPUrokinase-type plasminogen activator3.4.21.73

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fue7UPUrokinase-type plasminogen activator3.4.21.731.000
2vivVG2Urokinase-type plasminogen activator3.4.21.730.555
1sqtUI3Urokinase-type plasminogen activator3.4.21.730.525
3ig6438Urokinase-type plasminogen activator3.4.21.730.482
1ejnAGBUrokinase-type plasminogen activator3.4.21.730.466
2g004QCCoagulation factor X3.4.21.60.457
1xe55FEPlasmepsin-23.4.23.390.456
4fuiUI3Urokinase-type plasminogen activator3.4.21.730.453
1owe675Urokinase-type plasminogen activator3.4.21.730.445
2anmCDOProthrombin3.4.21.50.444
3egkM18Prothrombin3.4.21.50.443
2jh6894Prothrombin3.4.21.50.442
3v0xANHCationic trypsin3.4.21.40.441
2zi224UProthrombin3.4.21.50.440