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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.11.000
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.600
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.599
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.593
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.587
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.554
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.551
5av2KMPDeath-associated protein kinase 12.7.11.10.544
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.539
1jklANPDeath-associated protein kinase 12.7.11.10.526
3bqr4RBDeath-associated protein kinase 3/0.526
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.525
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.520
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.519
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.515
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.512
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.511
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.510
4jia1K3Tyrosine-protein kinase JAK2/0.504
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
2uzbC75Cyclin-dependent kinase 22.7.11.220.500
3gu7ADPDeath-associated protein kinase 12.7.11.10.499
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.498
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.497
5av3KMPDeath-associated protein kinase 12.7.11.10.496
2yaaATPDeath-associated protein kinase 2/0.490
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.490
4ysjADPCalmodulin-like domain protein kinase/0.490
2hog710Serine/threonine-protein kinase Chk12.7.11.10.489
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.489
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.486
4bcmT7ZCyclin-dependent kinase 22.7.11.220.486
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.485
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.485
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.483
4grb0XGCasein kinase II subunit alpha2.7.11.10.483
4aqc88ATyrosine-protein kinase JAK2/0.482
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.480
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.480
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.479
1jkkANPDeath-associated protein kinase 12.7.11.10.478
4j99ACPFibroblast growth factor receptor 2/0.473
3eb0DRKUncharacterized protein/0.472
2fvdLIACyclin-dependent kinase 22.7.11.220.470
4o0wADNAurora kinase A2.7.11.10.470
3nynSGVG protein-coupled receptor kinase 62.7.11.160.469
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.467
2w05FRTCyclin-dependent kinase 22.7.11.220.466
3gu83GUDeath-associated protein kinase 12.7.11.10.466
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.466
3zewSTUEphrin type-B receptor 42.7.10.10.466
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.466
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.465
5dosATPAurora kinase A2.7.11.10.465
5dt0SKEAurora kinase A2.7.11.10.465
3js2VM1Fibroblast growth factor receptor 1/0.463
3my5RFZCyclin-dependent kinase 22.7.11.220.463
1fvv107Cyclin-dependent kinase 22.7.11.220.462
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.462
3qxpX64Cyclin-dependent kinase 22.7.11.220.462
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.462
4f081RSTyrosine-protein kinase JAK2/0.461
4fv9E71Mitogen-activated protein kinase 12.7.11.240.461
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.461
4l9i8PRRhodopsin kinase/0.460
2vu3LZECyclin-dependent kinase 22.7.11.220.459
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.458
3pe2E1BCasein kinase II subunit alpha2.7.11.10.458
4eooATPCyclin-dependent kinase 22.7.11.220.458
2ckeIQUDeath-associated protein kinase 2/0.457
4anmWULCasein kinase II subunit alpha2.7.11.10.457
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.457
3be9P04Casein kinase II subunit alpha2.7.11.10.456
4hvi19STyrosine-protein kinase JAK32.7.10.20.456
1ig1ANPDeath-associated protein kinase 12.7.11.10.455
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.455
4j95ACPFibroblast growth factor receptor 2/0.455
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3at4CCKCasein kinase II subunit alpha2.7.11.10.453
4hge15VTyrosine-protein kinase JAK2/0.453
1yvj4STTyrosine-protein kinase JAK32.7.10.20.451
3bu5ATPInsulin receptor2.7.10.10.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2w4jADPDeath-associated protein kinase 12.7.11.10.450
3lltANPProtein serine/threonine kinase-1/0.450
4bbfO19Tyrosine-protein kinase JAK2/0.450
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.449
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.449
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.448
3nux3NVCyclin-dependent kinase 62.7.11.220.448
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.448
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.447
3lpbNVBTyrosine-protein kinase JAK2/0.447
3ztxZTXAurora kinase B-A2.7.11.10.447
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.447
1m2pHNACasein kinase II subunit alpha2.7.11.10.446
2j0lANPFocal adhesion kinase 12.7.10.20.446
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.446
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2vv9IM9Cyclin-dependent kinase 22.7.11.220.445
3axwTIDCasein kinase II subunit alpha2.7.11.10.445
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445
4aguD15Cyclin-dependent kinase-like 1/0.444
4wsqKSAAP2-associated protein kinase 12.7.11.10.444
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.443
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.442
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.442
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.442
4otiMI1Serine/threonine-protein kinase N1/0.442
5aut2ANDeath-associated protein kinase 12.7.11.10.442
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.441
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
4fv6E57Mitogen-activated protein kinase 12.7.11.240.441
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.440
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440