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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fob0USALK tyrosine kinase receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fob0USALK tyrosine kinase receptor2.7.10.11.000
4fod0UVALK tyrosine kinase receptor2.7.10.10.581
4foc0UUALK tyrosine kinase receptor2.7.10.10.539
4cd0AWJALK tyrosine kinase receptor2.7.10.10.532
2yfxVGHALK tyrosine kinase receptor2.7.10.10.529
2xp2VGHALK tyrosine kinase receptor2.7.10.10.528
5aaaVGHALK tyrosine kinase receptor2.7.10.10.523
4anqVGHALK tyrosine kinase receptor2.7.10.10.513
2xa4AZ5Tyrosine-protein kinase JAK2/0.503
4nk92K5Fibroblast growth factor receptor 1/0.502
4g1wG1WMitogen-activated protein kinase 82.7.11.240.498
5aacVGHALK tyrosine kinase receptor2.7.10.10.497
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
2itnANPEpidermal growth factor receptor2.7.10.10.490
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.490
4i22IREEpidermal growth factor receptor2.7.10.10.489
2xb7GUIALK tyrosine kinase receptor2.7.10.10.485
4ansVGHALK tyrosine kinase receptor2.7.10.10.485
4jia1K3Tyrosine-protein kinase JAK2/0.485
4b99R4LMitogen-activated protein kinase 72.7.11.240.483
2bfyH1NAurora kinase B-A2.7.11.10.480
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.480
4y93746Tyrosine-protein kinase/0.480
5e8xSTUTGF-beta receptor type-12.7.11.300.480
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.479
3a7hATPSerine/threonine-protein kinase 242.7.11.10.477
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4e730NRMitogen-activated protein kinase 82.7.11.240.474
2j0m4STFocal adhesion kinase 12.7.10.20.473
2qo9ANPEphrin type-A receptor 32.7.10.10.473
4ccbOFGALK tyrosine kinase receptor2.7.10.10.473
4nks2M2Fibroblast growth factor receptor 1/0.473
3pxkPXKFocal adhesion kinase 12.7.10.20.472
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2itqITQEpidermal growth factor receptor2.7.10.10.470
3t8oATPRhodopsin kinase/0.469
2j0lANPFocal adhesion kinase 12.7.10.20.468
4gmy0X5Tyrosine-protein kinase JAK2/0.468
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.465
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.465
2ijmATPFocal adhesion kinase 12.7.10.20.464
2ittAEEEpidermal growth factor receptor2.7.10.10.464
3c4xATPRhodopsin kinase/0.464
1bygSTUTyrosine-protein kinase CSK/0.463
4fnzNZFALK tyrosine kinase receptor2.7.10.10.463
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.462
3lctADPALK tyrosine kinase receptor2.7.10.10.462
3w2sW2REpidermal growth factor receptor2.7.10.10.462
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.461
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.461
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
5aabVGHALK tyrosine kinase receptor2.7.10.10.460
1pmn984Mitogen-activated protein kinase 102.7.11.240.459
2vgoAD5Aurora kinase B-A2.7.11.10.459
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.458
4c62XWWTyrosine-protein kinase JAK2/0.458
4y95746Tyrosine-protein kinase/0.458
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.457
3l8p0CEAngiopoietin-1 receptor2.7.10.10.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.456
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.456
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
2ituITQEpidermal growth factor receptor2.7.10.10.455
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.455
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.455
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.454
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.454
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.454
4id71G0Activated CDC42 kinase 1/0.454
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.453
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.453
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.452
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4wboANWRhodopsin kinase/0.452
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2pwlACPFibroblast growth factor receptor 2/0.450
3w33W19Epidermal growth factor receptor2.7.10.10.450
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4qo9627Serine/threonine-protein kinase 242.7.11.10.450
2itzIREEpidermal growth factor receptor2.7.10.10.449
3js2VM1Fibroblast growth factor receptor 1/0.449
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.449
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.448
2p33J07Mitogen-activated protein kinase 102.7.11.240.448
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3gubGUBDeath-associated protein kinase 12.7.11.10.448
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.448
3a62STURibosomal protein S6 kinase beta-12.7.11.10.447
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.447
4gk3L87Ephrin type-A receptor 32.7.10.10.447
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.446
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.446
2xvdAS6Ephrin type-B receptor 42.7.10.10.446
3vjoANPEpidermal growth factor receptor2.7.10.10.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
2hk51BMTyrosine-protein kinase HCK2.7.10.20.445
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.445
3emg685Tyrosine-protein kinase SYK2.7.10.20.445
3ormAGSSerine/threonine protein kinase/0.445
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.445
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.445
4gk4L90Ephrin type-A receptor 32.7.10.10.445
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.444
2itpAEEEpidermal growth factor receptor2.7.10.10.444
3uvqFS8Mitogen-activated protein kinase 14/0.444
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.444
2wqeADPAurora kinase A2.7.11.10.443
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.443
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.442
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.442
3zewSTUEphrin type-B receptor 42.7.10.10.442
4aacAAVMitogen-activated protein kinase 14/0.442
4j95ACPFibroblast growth factor receptor 2/0.442
4jrvKJVEpidermal growth factor receptor2.7.10.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
2acxANPG protein-coupled receptor kinase 62.7.11.160.441
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.441
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.441
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4ic7ANPMitogen-activated protein kinase 72.7.11.240.441
4nka2K7Fibroblast growth factor receptor 1/0.441
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.440
3k5uPFQAurora kinase A2.7.11.10.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440