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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fnyI3KALK tyrosine kinase receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fnyI3KALK tyrosine kinase receptor2.7.10.11.000
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.490
3tubFPUTyrosine-protein kinase SYK2.7.10.20.480
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.476
4tyj0LIFibroblast growth factor receptor 42.7.10.10.476
3ctj320Hepatocyte growth factor receptor2.7.10.10.474
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.470
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
3abaFLICytochrome P450/0.464
3cth319Hepatocyte growth factor receptor2.7.10.10.464
3f82353Hepatocyte growth factor receptor2.7.10.10.464
4qrc0LIFibroblast growth factor receptor 42.7.10.10.456
3eta351Insulin receptor2.7.10.10.452
3ce31FNHepatocyte growth factor receptor2.7.10.10.449
4iarERM5-hydroxytryptamine receptor 1B/0.449
3bu5ATPInsulin receptor2.7.10.10.443
4i22IREEpidermal growth factor receptor2.7.10.10.442