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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fl3ANPTyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fl3ANPTyrosine-protein kinase SYK2.7.10.21.000
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.547
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.511
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.506
3w33W19Epidermal growth factor receptor2.7.10.10.500
5cnnANPEpidermal growth factor receptor2.7.10.10.481
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.474
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.468
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.466
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.465
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
4jboWPHAurora kinase A2.7.11.10.457
4y95746Tyrosine-protein kinase/0.455
4jbpYPHAurora kinase A2.7.11.10.454
5cnoANPEpidermal growth factor receptor2.7.10.10.454
3vs3VSETyrosine-protein kinase HCK2.7.10.20.452
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.451
4y93746Tyrosine-protein kinase/0.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.449
4j95ACPFibroblast growth factor receptor 2/0.447
3ormAGSSerine/threonine protein kinase/0.445
4k33ACPFibroblast growth factor receptor 32.7.10.10.442
4jia1K3Tyrosine-protein kinase JAK2/0.440