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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkt48KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fkt48KCyclin-dependent kinase 22.7.11.221.000
2btrU73Cyclin-dependent kinase 22.7.11.220.674
2r3iSCFCyclin-dependent kinase 22.7.11.220.662
4ek610KCyclin-dependent kinase 22.7.11.220.656
2r3jSCJCyclin-dependent kinase 22.7.11.220.640
2r3p3SCCyclin-dependent kinase 22.7.11.220.617
1ykr628Cyclin-dependent kinase 22.7.11.220.609
4fkg4CKCyclin-dependent kinase 22.7.11.220.608
4fkq42KCyclin-dependent kinase 22.7.11.220.606
1pxmCK5Cyclin-dependent kinase 22.7.11.220.588
3r1yX76Cyclin-dependent kinase 22.7.11.220.587
4ek816KCyclin-dependent kinase 22.7.11.220.586
4fks46KCyclin-dependent kinase 22.7.11.220.586
4fkpLS5Cyclin-dependent kinase 22.7.11.220.585
2c6o4SPCyclin-dependent kinase 22.7.11.220.582
2c6iDT1Cyclin-dependent kinase 22.7.11.220.581
2vthLZ2Cyclin-dependent kinase 22.7.11.220.581
2uzoC62Cyclin-dependent kinase 22.7.11.220.580
1oirHDYCyclin-dependent kinase 22.7.11.220.576
1vyzN5BCyclin-dependent kinase 22.7.11.220.575
2a0cCK9Cyclin-dependent kinase 22.7.11.220.574
2r3lSCWCyclin-dependent kinase 22.7.11.220.572
1pxlCK4Cyclin-dependent kinase 22.7.11.220.571
4fki09KCyclin-dependent kinase 22.7.11.220.570
2w17I19Cyclin-dependent kinase 22.7.11.220.569
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.568
3lfqA28Cyclin-dependent kinase 22.7.11.220.566
3rni21ZCyclin-dependent kinase 22.7.11.220.564
3r8lZ30Cyclin-dependent kinase 22.7.11.220.563
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.560
1ke5LS1Cyclin-dependent kinase 22.7.11.220.558
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.558
2xmyCDKCyclin-dependent kinase 22.7.11.220.558
2w05FRTCyclin-dependent kinase 22.7.11.220.554
3ezvEZVCyclin-dependent kinase 22.7.11.220.554
3lfnA27Cyclin-dependent kinase 22.7.11.220.554
1pxoCK7Cyclin-dependent kinase 22.7.11.220.553
1oitHDTCyclin-dependent kinase 22.7.11.220.552
3s2pPMUCyclin-dependent kinase 22.7.11.220.552
3qzgX67Cyclin-dependent kinase 22.7.11.220.549
1w8cN69Cyclin-dependent kinase 22.7.11.220.546
2r3r6SCCyclin-dependent kinase 22.7.11.220.543
4fkj11KCyclin-dependent kinase 22.7.11.220.543
4fklCK2Cyclin-dependent kinase 22.7.11.220.543
2uznC96Cyclin-dependent kinase 22.7.11.220.542
1p2a5BNCyclin-dependent kinase 22.7.11.220.541
3fz1B98Cyclin-dependent kinase 22.7.11.220.540
1y8yCT7Cyclin-dependent kinase 22.7.11.220.539
3r7yZ04Cyclin-dependent kinase 22.7.11.220.537
1b38ATPCyclin-dependent kinase 22.7.11.220.536
1g5sI17Cyclin-dependent kinase 22.7.11.220.535
2r3kSCQCyclin-dependent kinase 22.7.11.220.534
2w06FRVCyclin-dependent kinase 22.7.11.220.534
1gih1PUCyclin-dependent kinase 22.7.11.220.532
3qxoX65Cyclin-dependent kinase 22.7.11.220.532
2c6lDT4Cyclin-dependent kinase 22.7.11.220.530
2b53D23Cyclin-dependent kinase 22.7.11.220.529
1ke7LS3Cyclin-dependent kinase 22.7.11.220.528
2b52D42Cyclin-dependent kinase 22.7.11.220.528
2btsU32Cyclin-dependent kinase 22.7.11.220.526
1b39ATPCyclin-dependent kinase 22.7.11.220.525
2vv9IM9Cyclin-dependent kinase 22.7.11.220.525
1gii1PUCyclin-dependent kinase 22.7.11.220.524
1w0xOLOCyclin-dependent kinase 22.7.11.220.524
2a4lRRCCyclin-dependent kinase 22.7.11.220.524
2r3mSCXCyclin-dependent kinase 22.7.11.220.523
3r7uX96Cyclin-dependent kinase 22.7.11.220.523
4bgh3I6Cyclin-dependent kinase 22.7.11.220.522
4fkr45KCyclin-dependent kinase 22.7.11.220.522
3qtxX43Cyclin-dependent kinase 22.7.11.220.520
3rjc06ZCyclin-dependent kinase 22.7.11.220.520
3qtuX44Cyclin-dependent kinase 22.7.11.220.519
4fko20KCyclin-dependent kinase 22.7.11.220.519
2r64740Cyclin-dependent kinase 22.7.11.220.518
3le62BZCyclin-dependent kinase 22.7.11.220.518
3pj8404Cyclin-dependent kinase 22.7.11.220.518
3pxyJWSCyclin-dependent kinase 22.7.11.220.518
3rak03ZCyclin-dependent kinase 22.7.11.220.518
3rpv26ZCyclin-dependent kinase 22.7.11.220.518
3s1h56ZCyclin-dependent kinase 22.7.11.220.517
2r3gSC9Cyclin-dependent kinase 22.7.11.220.516
2r3q5SCCyclin-dependent kinase 22.7.11.220.516
1pxpCK8Cyclin-dependent kinase 22.7.11.220.514
3iggEFQCyclin-dependent kinase 22.7.11.220.514
2c6kDT2Cyclin-dependent kinase 22.7.11.220.513
2exmZIPCyclin-dependent kinase 22.7.11.220.510
3rm719ZCyclin-dependent kinase 22.7.11.220.510
4ez30S0Cyclin-dependent kinase 22.7.11.220.510
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.509
3qqlX03Cyclin-dependent kinase 22.7.11.220.509
3rk708ZCyclin-dependent kinase 22.7.11.220.508
4fkv61KCyclin-dependent kinase 22.7.11.220.508
3qtzX42Cyclin-dependent kinase 22.7.11.220.507
1ke6LS2Cyclin-dependent kinase 22.7.11.220.506
3qqhX0ACyclin-dependent kinase 22.7.11.220.506
3rmf20ZCyclin-dependent kinase 22.7.11.220.504
4acm7YGCyclin-dependent kinase 22.7.11.220.504
4fkw62KCyclin-dependent kinase 22.7.11.220.504
3raiX85Cyclin-dependent kinase 22.7.11.220.501
1h1s4SPCyclin-dependent kinase 22.7.11.220.500
3qu0X40Cyclin-dependent kinase 22.7.11.220.500
3qwjX6ACyclin-dependent kinase 22.7.11.220.499
3ral04ZCyclin-dependent kinase 22.7.11.220.499
3r7vZ02Cyclin-dependent kinase 22.7.11.220.497
3r9dX6BCyclin-dependent kinase 22.7.11.220.497
3r8vZ62Cyclin-dependent kinase 22.7.11.220.496
1aq1STUCyclin-dependent kinase 22.7.11.220.495
2bheBRYCyclin-dependent kinase 22.7.11.220.493
2vtrLZBCyclin-dependent kinase 22.7.11.220.493
1oguST8Cyclin-dependent kinase 22.7.11.220.492
1urwI1PCyclin-dependent kinase 22.7.11.220.492
3sw719KCyclin-dependent kinase 22.7.11.220.492
1ckpPVBCyclin-dependent kinase 22.7.11.220.490
3r73X87Cyclin-dependent kinase 22.7.11.220.490
1v1k3FPCyclin-dependent kinase 22.7.11.220.489
3lfsA07Cyclin-dependent kinase 22.7.11.220.489
3r83Z14Cyclin-dependent kinase 22.7.11.220.489
3sqq99ZCyclin-dependent kinase 22.7.11.220.489
3rk507ZCyclin-dependent kinase 22.7.11.220.486
3unk0BYCyclin-dependent kinase 22.7.11.220.486
3roy22ZCyclin-dependent kinase 22.7.11.220.485
4nj32KDCyclin-dependent kinase 22.7.11.220.485
1h0vUN4Cyclin-dependent kinase 22.7.11.220.484
3qxpX64Cyclin-dependent kinase 22.7.11.220.484
3r7iX9ICyclin-dependent kinase 22.7.11.220.484
3rk909ZCyclin-dependent kinase 22.7.11.220.484
1pyePM1Cyclin-dependent kinase 22.7.11.220.482
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.482
1ke8LS4Cyclin-dependent kinase 22.7.11.220.481
3r1sX73Cyclin-dependent kinase 22.7.11.220.481
2duv371Cyclin-dependent kinase 22.7.11.220.480
2r3o2SCCyclin-dependent kinase 22.7.11.220.478
2r3fSC8Cyclin-dependent kinase 22.7.11.220.477
3py0SU9Cyclin-dependent kinase 22.7.11.220.477
3rpo24ZCyclin-dependent kinase 22.7.11.220.477
1fvv107Cyclin-dependent kinase 22.7.11.220.476
1y91CT9Cyclin-dependent kinase 22.7.11.220.476
1ke9LS5Cyclin-dependent kinase 22.7.11.220.475
4fx360KCyclin-dependent kinase 22.7.11.220.475
1pxkCK3Cyclin-dependent kinase 22.7.11.220.474
2iw84SPCyclin-dependent kinase 22.7.11.220.474
3r71X86Cyclin-dependent kinase 22.7.11.220.474
3rpy27ZCyclin-dependent kinase 22.7.11.220.474
2b54D05Cyclin-dependent kinase 22.7.11.220.473
3qtrX36Cyclin-dependent kinase 22.7.11.220.473
4erwSTUCyclin-dependent kinase 22.7.11.220.471
2w1hL0FCyclin-dependent kinase 22.7.11.220.470
2x1nX1NCyclin-dependent kinase 22.7.11.220.470
3wblPDYCyclin-dependent kinase 22.7.11.220.470
1fvt106Cyclin-dependent kinase 22.7.11.220.469
2vtsLZCCyclin-dependent kinase 22.7.11.220.469
3qzhX69Cyclin-dependent kinase 22.7.11.220.469
3sheI85MAP kinase-activated protein kinase 32.7.11.10.469
3ti1B49Cyclin-dependent kinase 22.7.11.220.468
4aua4AUCyclin-dependent kinase 62.7.11.220.467
3rm618ZCyclin-dependent kinase 22.7.11.220.466
1oiqHDUCyclin-dependent kinase 22.7.11.220.465
3rzb02ZCyclin-dependent kinase 22.7.11.220.465
3unj0BXCyclin-dependent kinase 22.7.11.220.465
4lyn1YGCyclin-dependent kinase 22.7.11.220.465
2iw94SPCyclin-dependent kinase 22.7.11.220.464
2vttLZDCyclin-dependent kinase 22.7.11.220.464
1e1xNW1Cyclin-dependent kinase 22.7.11.220.461
1h1r6CPCyclin-dependent kinase 22.7.11.220.460
3ig7EFPCyclin-dependent kinase 22.7.11.220.460
1dm2HMDCyclin-dependent kinase 22.7.11.220.459
3qqkX02Cyclin-dependent kinase 22.7.11.220.459
4eon1ROCyclin-dependent kinase 22.7.11.220.459
2c6tDT5Cyclin-dependent kinase 22.7.11.220.458
1hckATPCyclin-dependent kinase 22.7.11.220.457
3rahO1ZCyclin-dependent kinase 22.7.11.220.457
3sw418KCyclin-dependent kinase 22.7.11.220.457
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.455
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.455
3nynSGVG protein-coupled receptor kinase 62.7.11.160.455
3qqfX07Cyclin-dependent kinase 22.7.11.220.455
1di8DTQCyclin-dependent kinase 22.7.11.220.454
1oi9N20Cyclin-dependent kinase 22.7.11.220.454
1pxjCK2Cyclin-dependent kinase 22.7.11.220.454
3ezrEZRCyclin-dependent kinase 22.7.11.220.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.453
2xnbY8LCyclin-dependent kinase 22.7.11.220.453
3qzfX66Cyclin-dependent kinase 22.7.11.220.453
3r6xX84Cyclin-dependent kinase 22.7.11.220.453
3r9oZ71Cyclin-dependent kinase 22.7.11.220.453
4eor4SPCyclin-dependent kinase 22.7.11.220.453
1h0w207Cyclin-dependent kinase 22.7.11.220.452
1h1q2A6Cyclin-dependent kinase 22.7.11.220.452
2bhhRYUCyclin-dependent kinase 22.7.11.220.452
2c5yMTWCyclin-dependent kinase 22.7.11.220.452
3r28XA0Cyclin-dependent kinase 22.7.11.220.452
4eok4SPCyclin-dependent kinase 22.7.11.220.452
4kd11QKCyclin-dependent kinase 22.7.11.220.452
2eufLQQCyclin-dependent kinase 62.7.11.220.451
3qqgX06Cyclin-dependent kinase 22.7.11.220.451
3r9hZ67Cyclin-dependent kinase 22.7.11.220.450
1eh4IC1Casein kinase I homolog 12.7.11.10.449
3s0o50ZCyclin-dependent kinase 22.7.11.220.448
2c6mDT5Cyclin-dependent kinase 22.7.11.220.446
1vyw292Cyclin-dependent kinase 22.7.11.220.445
3bhtMFRCyclin-dependent kinase 22.7.11.220.445
3uli1N3Cyclin-dependent kinase 22.7.11.220.445
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.444
1r78FMDCyclin-dependent kinase 22.7.11.220.443
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.443
2wihP48Cyclin-dependent kinase 22.7.11.220.443
3qtqX35Cyclin-dependent kinase 22.7.11.220.443
2pvnP63Casein kinase II subunit alpha2.7.11.10.442
3r7eX88Cyclin-dependent kinase 22.7.11.220.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
4eomATPCyclin-dependent kinase 22.7.11.220.441
1gij2PUCyclin-dependent kinase 22.7.11.220.440